Randomized comparison of the effects of endocervical and vaginal prostaglandin E2 gel in women with various degrees of cervical ripeness. Dutch Collaborative Prostaglandin Trialists' Group

American Journal of Obstetrics and Gynecology
M J Keirse, H J de Koning Gans

Abstract

The trail was conducted to obtain an unbiased comparison of the relative merits of endocervical and vaginal prostaglandin E2 gel in a weighted case mix of parous and nulliparous women with favorable and unfavorable cervical features. Multicenter randomized trial with 285 participants, (three exclusions) was performed with sealed envelopes stratified for parity and Bishop score. Outcomes of labor and delivery were clearly related to the cervical score at trial entry, especially in nulliparous women. Endocervical prostaglandin E2 had a more marked effect on cervical ripeness than did vaginal prostaglandin E2, but this did not result in any differences in more substantive outcomes. Frequencies of delivery within 12 (50%) and 24 hours (77.7%), cesarean section (7.3%), instrumental vaginal delivery (11.7%), and poor infant outcomes were similar with both preparations. Because differences in effectiveness between endocervical and vaginal prostaglandin E2 in triacetin gel are marginal, preferences of women and clinicians can determine the choice between them.

References

Dec 1, 1992·Baillière's Clinical Obstetrics and Gynaecology·M J Keirse
Nov 26, 1991·European Journal of Obstetrics, Gynecology, and Reproductive Biology·J LyndrupT Weber
Oct 11, 1991·American Journal of Obstetrics and Gynecology·J OwenM C Smith
Mar 1, 1984·Prostaglandins·M ThieryK De Geest

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Citations

Aug 4, 2006·Clinical Obstetrics and Gynecology·Marc J N C Keirse
Jan 8, 2004·American Journal of Obstetrics and Gynecology·Erling EkerhovdAnders Norström
Aug 11, 2007·The Journal of Obstetrics and Gynaecology Research·Mohamed Furukan Mohamed Rameez, Indra Malik Rodrigo Goonewardene
Feb 7, 2008·The Cochrane Database of Systematic Reviews·M BoulvainO Irion
Jan 1, 2014·International Journal of Reproductive Medicine·Kavita AgarwalAbha Aggarwal
Jun 23, 2012·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Kavita AgarwalAbha Aggarwal

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