PMID: 2499178Jun 1, 1989Paper

Randomized comparison of viral oncolysate plus radiation and radiation alone in uterine cervix carcinoma

American Journal of Clinical Oncology
R S FreedmanB Patenia

Abstract

A randomized, controlled study was performed in patients with high-risk, untreated squamous cell carcinoma of the uterine cervix to evaluate the adjunctive use of viral oncolysate (VO) prepared from the SW756 cell line. Seventy-five patients were stratified by tumor volume and randomized to receive radiation therapy (RT) alone or RT plus intradermal immunization with VO. Fifty-one (68%) patients relapsed with a median survival (MS) of 29.1 months and a median progression-free interval (MPFI) of 18.0 months. No differences in MS or median PFI were observed by treatment arm or site of relapse, although a trend toward improved MS and median PFI in patients with small-volume primary lesions was suggested. Serum surface-binding antibody activity (greater than or equal to 1:8) to the SW756 cell line was detected in 14 of 41 unselected patients prior to therapy. Virus hemagglutination inhibitory activity (greater than or equal to 1:8) was detected in 37 of 41 patients before treatment. four-fold increases in titer were observed to the SW756 cell line in 83% and to influenza in 74% of patients tested after immunization. Preirradiation measurements of phytohemagglutinin-induced blastogenesis by the relative proliferation index (RPI) met...Continue Reading

Citations

Nov 4, 2000·Expert Opinion on Investigational Drugs·E R Smith, E A Chiocca
Dec 1, 2006·Veterinary and Comparative Oncology·D H Thamm
Nov 19, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G CuriglianoA Goldhirsch
Sep 26, 2007·Expert Review of Anticancer Therapy·Giuseppe CuriglianoAron Goldhirsch
Jan 1, 1991·International Reviews of Immunology·C G Ioannides, R S Freedman

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