Abstract
Nasal continuous positive airway pressure (NCPAP) is an accepted form of non-invasive ventilation in preterm infants. Few, if any, studies have shown an advantage of one type of NCPAP over another. It has been theorized that bubble-generated NCPAP may be advantageous for the preterm neonate versus traditionally used ventilator-generated NCPAP. The aim of this study was to examine for any short-term differences in physiologic parameters in preterm subjects receiving these two different methods of NCPAP. We conducted a randomized, prospective, cross-over pilot study of preterm infants being treated with NCPAP in the neonatal intensive care unit. Subjects were continuously monitored for several physiologic parameters including heart rate, respiratory rate, oxygen saturation, cerebral tissue oxygen saturation and cerebral fractional oxygen extraction using routine neonatal monitors and near-infrared spectroscopy (NIRS) while on 2 h of bubble NCPAP and 2 h of ventilator NCPAP. Subjects were randomized to be monitored while either starting on bubble NCPAP and then switching to ventilator NCPAP or starting on ventilator NCPAP and switching to bubble NCPAP. Eighteen subjects were included. We found no statistically significant differen...Continue Reading
References
Jun 1, 1977·The Journal of Pediatrics·R J MartinM H Klaus
Jul 1, 1978·Pediatric Research·C P Richardson, A L Jung
Jan 1, 1991·Pediatric Pulmonology·R LockeM R Wolfson
Jan 1, 1990·Journal of Applied Physiology·M J MillerR J Martin
Mar 1, 1990·Journal of Applied Physiology·J S WyattE O Reynolds
Jun 17, 1971·The New England Journal of Medicine·G A GregoryW K Hamilton
Mar 4, 1998·Biology of the Neonate·K S LeeA T Shennan
Aug 17, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·C Morley
Oct 3, 2002·Pediatric Research·J Jane PillowJason H T Bates
Apr 30, 2003·Archives of Disease in Childhood. Fetal and Neonatal Edition·A G De PaoliP G Davis
Nov 5, 2003·Pediatrics·Beatrice M StefanescuJudy L Aschner
Mar 19, 2005·Pediatric Research·J Jane Pillow, Javeed N Travadi
Mar 23, 2007·Neonatology·Gunnar NaulaersHugo Devlieger
Apr 14, 2007·American Journal of Respiratory and Critical Care Medicine·J Jane PillowAlan H Jobe
Aug 24, 2007·Acta Paediatrica·Carlo DaniFirmino F Rubaltelli
Jan 27, 2009·Pediatrics and Neonatology·Wen-Chin HuangYeong-Seng Yuh
Feb 24, 2009·The Journal of Pediatrics·Samir GuptaSteven M Donn
Jun 19, 2009·Current Neurovascular Research·Lucia Gabriella TinaDiego Gazzolo
Mar 24, 2010·Pediatric Research·Robert M DiblasiC Peter Richardson
Sep 4, 2010·Pediatric Research·Robert M DiblasiC Peter Richardson
Jan 22, 2011·Journal of Perinatology : Official Journal of the California Perinatal Association·A PetrovaR Mehta
Oct 18, 2011·BMC Pediatrics·Christine L RobertsNatasha Nassar
Feb 11, 2015·Pediatric Research·Annemiek M RoescherElise A Verhagen