Randomized control trial comparing physiologic effects in preterm infants during treatment with nasal continuous positive airway pressure (NCPAP) generated by Bubble NCPAP and Ventilator NCPAP: a pilot study

Journal of Perinatal Medicine
Craig GuerinShantanu Rastogi

Abstract

Nasal continuous positive airway pressure (NCPAP) is an accepted form of non-invasive ventilation in preterm infants. Few, if any, studies have shown an advantage of one type of NCPAP over another. It has been theorized that bubble-generated NCPAP may be advantageous for the preterm neonate versus traditionally used ventilator-generated NCPAP. The aim of this study was to examine for any short-term differences in physiologic parameters in preterm subjects receiving these two different methods of NCPAP. We conducted a randomized, prospective, cross-over pilot study of preterm infants being treated with NCPAP in the neonatal intensive care unit. Subjects were continuously monitored for several physiologic parameters including heart rate, respiratory rate, oxygen saturation, cerebral tissue oxygen saturation and cerebral fractional oxygen extraction using routine neonatal monitors and near-infrared spectroscopy (NIRS) while on 2 h of bubble NCPAP and 2 h of ventilator NCPAP. Subjects were randomized to be monitored while either starting on bubble NCPAP and then switching to ventilator NCPAP or starting on ventilator NCPAP and switching to bubble NCPAP. Eighteen subjects were included. We found no statistically significant differen...Continue Reading

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Citations

Jan 24, 2020·Archives of Disease in Childhood. Fetal and Neonatal Edition·Shruti K BharadwajAmit Mukerji
May 11, 2018·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Samantha Alessi

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Methods Mentioned

BETA
Infrared Spectroscopy

Software Mentioned

SPSS
ixTrend
INVOS

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