Randomized control trial of opioid- versus nonopioid-based analgesia after thyroidectomy

Surgery
Vardan PapoianErin A Felger

Abstract

Opioid-based analgesia is the most common method for pain control in the postoperative period. Limited data exist to compare the adequacy of pain control in the post thyroidectomy period with nonopioid-based analgesia. We aimed to evaluate the efficacy of nonopioid-based, postoperative analgesia. After institutional review board approval, patients were randomized to 1 of 2 pain control regimens. Sample size was calculated to assess for a pain score difference of 1 based on a visual analog scale. The control group received opioid-based, postoperative analgesia, whereas the study group received nonopioid-based analgesia of acetaminophen and ibuprofen. Pain scores (measured on visual analog scale) and opioid use (converted to morphine equivalent dose) were measured after completion of the operation. The sample sizes for the study and control groups were 49 and 46 patients, respectively. The pain score for the study and control groups 1 hour after the operation (3.3 vs 3.9, P = .35), 6 hours after the operation (2.8 vs 3.0, P = .08), on postoperative day 1 (1.6 vs 2.4, P = .08) and on the first office visit (0.2 vs 0.1, P = .82) did not have a statistically significant difference. Morphine equivalent opioid requirement for pain con...Continue Reading

Citations

Aug 19, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·John D CramerMichael J Brenner
Aug 9, 2020·Annals of Surgical Oncology·Avani R PatelUNKNOWN Permanente Medical Group Breast Research Collaborative
Mar 3, 2021·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Punam A PatelCecelia E Schmalbach
Jul 15, 2021·American Journal of Surgery·Joana E OchoaJames X Wu
Nov 5, 2021·The American Surgeon·Preston W LeaderReese W Randle

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