Apr 11, 2001

Randomized, controlled chemoprevention trials in populations at very high risk for prostate cancer: Elevated prostate-specific antigen and high-grade prostatic intraepithelial neoplasia

Urology
L C Clark, J R Marshall

Abstract

This is a report of research efforts underway at the Arizona Cancer Center. These efforts build upon Larry Clark's unanticipated clinical prevention trial results: those results indicated that 200 microg/day of selenium in selenized yeast decreased prostate cancer risk by almost 60%. The trials underway address various phases of the possible preventive activity of selenium. The first of these, for men who are suspected to have prostate cancer but who have had a biopsy revealing no evidence of cancer, will test the ability of selenium to prevent the development of clinical prostate cancer. The second is for men with high-grade prostatic intraepithelial neoplasia; the trial will test whether selenium will prevent the development of prostatic cancer in this high-risk group. The third trial is for men who have been diagnosed with prostate cancer and are scheduled for prostatectomy: the trial is designed to test whether evidence of selenium-linked changes can be identified in the tissue removed at prostatectomy. The fourth trial is for men who have been diagnosed with prostate cancer but who have chosen neither surgery nor irradiation; this trial will evaluate whether treatment with selenium will inhibit the progress of prostate can...Continue Reading

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  • Citations20

References

Mentioned in this Paper

Malignant Neoplasm of Skin
Prostatic Neoplasms
Neoplasm Recurrence, Local
Prostatectomy, Suprapubic
Cervical Intraepithelial Neoplasia
Pigmented Basal Cell Carcinoma
Squamous Cell Carcinoma
Anticarcinogenic Effect
Prostate-Specific Antigen
Selenomethionine, (S)-Isomer

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