Randomized controlled study of a novel triple nitazoxanide (NTZ)-containing therapeutic regimen versus the traditional regimen for eradication of Helicobacter pylori infection

Helicobacter
Mona Ah ShehataSherief Abd-Elsalam

Abstract

Helicobacter pylori infection has become more and more resistant to conventional first-line treatment regimens. So, there is a considerable interest in evaluating new antibiotic combinations and regimens. Nitazoxanide is an anti-infective drug with demonstrated activity against protozoa and anaerobic bacteria including H. pylori. This work is designed to evaluate the efficacy and safety of a unique triple nitazoxanide-containing regimen as a treatment regimen in Egyptian patients with H. pylori infection. Two hundred and 24 patients with upper gastrointestinal tract (GIT) dyspeptic symptoms in whom H. pylori -induced GIT disease was confirmed were included in the study. They have been randomized to receive either nitazoxanide 500 mg b.i.d., clarithromycin 500 mg b.i.d., and omeprazole 40 mg twice daily for 14 days or metronidazole 500 mg b.i.d., clarithromycin 500 mg b.i.d., and omeprazole 40  mg twice daily for 14 days. Laboratory evaluation for H. pylori antigen within the stool was performed 6 weeks after cessation of H. pylori treatment regimens to assess the response. The response to treatment was significantly higher in group 1 of nitazoxanide treatment regimen than group 2 of traditional treatment regimen. One hundred an...Continue Reading

Associated Clinical Trials

References

Nov 26, 2003·Critical Reviews in Microbiology·Rinaldo PellicanoAntonio Ponzetto
Nov 26, 2003·Antimicrobial Agents and Chemotherapy·Yvonne GuttnerBarry J Marshall
Oct 22, 2005·Digestive Diseases and Sciences·Selim AydemirYucel Ustundag
Dec 23, 2014·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yi-Chia LeeMing-Shiang Wu
Nov 2, 2016·Gut·P MalfertheinerUNKNOWN European Helicobacter and Microbiota Study Group and Consensus panel
Jan 11, 2017·The American Journal of Gastroenterology·William D CheySteven F Moss

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Citations

Sep 12, 2018·Helicobacter·Neil R O'MorainColm A O'Morain
May 31, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Amany Mohamed Abo-EleneinSherief Abd-Elsalam
Apr 7, 2018·Therapeutic Advances in Chronic Disease·Xavier Calvet
Mar 19, 2019·Gastroenterology Research and Practice·Mohamed A ElsebaeySherief Abd-Elsalam
Jul 25, 2019·World Journal of Gastroenterology : WJG·Stella SmithRinaldo Pellicano

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