Randomized controlled study of pre-conception thromboprophylaxis among patients with recurrent spontaneous abortion related to antiphospholipid syndrome.

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Alaa M IsmailAymen N Abdelmeged

Abstract

To investigate the effects of pre-conception thromboprophylaxis among patients with recurrent spontaneous abortion and antiphospholipid syndrome. A randomized placebo-controlled trial enrolled patients with a history of recurrent spontaneous abortions and antiphospholipid syndrome who attended an Egyptian center between January 2011 and June 2013. Using a computer-generated sequence, patients were randomly allocated to receive 41 mg enoxaparin subcutaneously plus 81 mg aspirin daily pre-conception, or to receive placebo pre-conception. All patients received enoxaparin and aspirin following identification of fetal heart pulsation. The primary outcomes were live-birth rate and clinical-pregnancy rate at 0-6 months, and at 6-12 months. Intention-to-treat analyses were performed. Clinicians, investigators, and data analysts were masked to the treatment assignments. The study enrolled 180 patients(90 in each group). No significant difference was observed between the intervention and control groups in the live-birth rate (67[74%] vs 59[66%]; P=0.25). At 0-6 months, the clinical-pregnancy rate was higher in the intervention group (50[56%]vs 30[33%], P=0.02). No significant difference between the intervention and control groups was obs...Continue Reading

References

Jun 1, 1992·Journal of Reproductive Immunology·T W LydenN S Rote
Aug 5, 2004·Obstetrics and Gynecology·Siobhan QuenbyGill Vince
Jan 27, 2005·American Journal of Obstetrics and Gynecology·Patrick BoseBerthold Huppertz
Apr 12, 2005·Fertility and Sterility·Ole B ChristiansenKatrin van der Ven
Aug 15, 2006·Lancet·Raj Rai, Lesley Regan
Nov 6, 2009·Thrombosis and Haemostasis·Jin-Ping Li, Israel Vlodavsky
Mar 26, 2010·The New England Journal of Medicine·Stef P KaandorpSaskia Middeldorp

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Citations

Jul 14, 2018·The Cochrane Database of Systematic Reviews·Malgorzata M BalaAnetta Undas
Dec 18, 2018·The Cochrane Database of Systematic Reviews·Aleena M WojcieszekVicki Flenady
Nov 29, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Chang LuHai-Li Jiang
Apr 16, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Yangming LiuHongbo Qi
May 1, 2018·American Journal of Reproductive Immunology : AJRI·Sha LvXiaoxiao Xu
Mar 10, 2021·Journal of Thrombosis and Haemostasis : JTH·Eva N HamulyákSaskia Middeldorp

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Related Concepts

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Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

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