Randomized controlled trial assessing two commercial weight loss programs in adults with overweight or obesity

Obesity Science & Practice
L M ArterburnC M Cook

Abstract

Lifestyle interventions remain the cornerstone for obesity treatment. Commercial programs offer one weight loss approach, yet the efficacy of few such programs have been rigorously investigated. The purpose of this study was to evaluate the efficacy of two commercial weight-loss programs, both utilizing pre-portioned meal replacements (MRs) and different levels of behavioural support, compared to a self-directed control diet in adults with overweight and obesity. In this 16-week study, participants were randomized to the low-calorie OPTAVIA® 5&1 Plan® with telephone coaching (OPT), the reduced-calorie Medifast® 4&2&1 self-guided plan (MED), or a self-directed, reduced-calorie control diet. Differences in weight, body composition (DXA) and body circumferences, all measured monthly, were assessed by analysis of covariance with sex and baseline measures as covariates. Of 198 participants randomized (80.8% female, BMI 34.2 kg/m2, 45.7 years), 92.3% completed the study. The OPT and MED groups had significantly greater reductions in body weight (-5.7% and - 5.0%, respectively, p < 0.0001), fat and abdominal fat mass (p < 0.0001) and waist and hip circumferences (p ≤ 0.003) than control at 16 weeks. Weight change was correlated with M...Continue Reading

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Citations

Mar 15, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Sara DielsWim Van Hul
Jun 1, 2019·Journal of Primary Care & Community Health·Hope D KleineJessica R Meendering
Feb 21, 2021·Current Obesity Reports·Marci LaudenslagerKimberly A Gudzune

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Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

OPTAVIA®
enCORE
ChooseMyPlate
IntegReview
Medifast
OPTAVIA
SAS

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