Randomized Controlled Trial Comparing the Efficacy of Terlipressin and Albumin with a Combination of Concurrent Dopamine, Furosemide, and Albumin in Hepatorenal Syndrome

Journal of Clinical and Experimental Hepatology
Siddharth SrivastavaSubrat K Acharya

Abstract

Terlipressin with albumin is recommended in hepatorenal syndrome (HRS). Terlipressin is expensive and not licensed in many countries. Alternative therapy is necessary. We compared the efficacy of terlipressin and albumin with concurrent low-dose dopamine, furosemide, and albumin in HRS. In an open-label, randomized trial, forty consecutive patients each with HRS type I and HRS type II received either concurrent infusion of terlipressin 0.5 mg for every 6 hr and albumin 20 g/day for 5 days (n = 20) or a combination of dopamine 2 μg/kg/min, furosemide 0.01 mg/kg/hr, and albumin 20 g/day (triple therapy), in one of two therapeutic arms. Twenty-four-hour urine output, urinary sodium, and plasma renin activity (PRA) were assessed before and after treatment. The two groups were comparable at baseline in both HRS-I and II. In HRS-I, 24 hr urine output and urine sodium at the end of 5 days increased in both treatment groups (terlipressin, urine output 278 ± 136 to 765 ± 699 ml/day, P < 0.01; urine sodium 28 ± 25.1 to 39 ± 32.1 meq/l, P = 0.05. Triple therapy: urine output 219 ± 134 to 706 ± 595 ml/day, P < 0.01; urine sodium 25 ± 18.3 to 41 ± 27.5 meq/l, P < 0.01). PRA (ng/ml/hr) decreased from 28.1 ± 9.76 to 24.2 ± 9.5 (P = 0.01) and ...Continue Reading

References

Sep 13, 1993·Archives of Internal Medicine·S BadalamentiC Ponticelli
Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M GuevaraJ Rodés
May 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P AngeliA Gatta
Jan 25, 2003·Journal of Gastroenterology and Hepatology·Prashant SolankiShiv K Sarin
Mar 30, 2007·Journal of Hepatology·Vicente ArroyoPere Ginès
Aug 5, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Massimo CazzanigaMassimo Cugno
Aug 5, 2010·Gastroenterology·Marta Martín-LlahíPere Ginès
Aug 10, 2010·Journal of Vascular and Interventional Radiology : JVIR·Curtis L AndersonJohn F Angle
Sep 7, 2011·Gastroenterology Clinics of North America·Wesley Leung, Florence Wong
Feb 1, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Kenneth S H ChokChung Mau Lo

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Citations

Feb 24, 2016·Journal of Clinical and Experimental Hepatology·Salvatore Piano, Paolo Angeli
Jan 5, 2017·Alimentary Pharmacology & Therapeutics·F J GiffordJ A Fallowfield
Mar 16, 2017·World Journal of Hepatology·Juan G Acevedo, Matthew E Cramp
Apr 11, 2018·European Journal of Gastroenterology & Hepatology·Shuan ZhangZhi-Yun Yang
Nov 27, 2018·Current Medical Research and Opinion·Jingqiao ZhangXingshun Qi
Sep 13, 2019·The Cochrane Database of Systematic Reviews·Lawrence Mj BestKurinchi Selvan Gurusamy
Sep 28, 2017·The Cochrane Database of Systematic Reviews·Mads IsraelsenLise Lotte Gluud
Sep 5, 2018·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Riyaz U SaifShowkat Ali Zargar
Feb 6, 2021·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·Irtiza HasanHani M Wadei
May 18, 2021·Journal of Clinical and Experimental Hepatology·Anil AroraSantosh Varughese
Aug 29, 2017·Kidney International·Andrew DavenportRajiv Jalan

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