Randomized controlled trial: effects of diet on DNA damage in heavy smokers

Mutagenesis
G TalaskaPaolo Vineis

Abstract

We have conducted a randomized trial which investigated the ability of dietary changes (in particular diets rich in cruciferous vegetables and flavonoids), to increase urinary antimutagenicity and inhibit DNA damage in smokers. Ninety heavy smokers were recruited and randomly assigned to three groups, and were given three different diets. The first diet was based on flavonoid-rich foods, particularly cruciferous vegetables, but not based on supplementation; the second was a normal isocaloric diet (with an adequate administration of fruits and vegetables); and the third was based on supplementation of flavonoids in the form of green tea and soy products. DNA adducts were measured by (32)P-postlabelling in exfoliated bladder cells at different times since the start of the trial. In spite of randomization, subjects in the control group smoked more than those in the experimental groups, and this can explain the higher adduct levels at baseline. A slight decrease in bulky DNA adducts in exfoliated bladder cells was observed after 1 year since the end in the supplementation group and after 1 month in white blood cells. The only statistically significant association was found in a regression model that adjusted for smoking, in which t...Continue Reading

References

Dec 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J V Formica, W Regelson
May 23, 2002·Carcinogenesis·Luisa AiroldiPaolo Vineis
Mar 3, 2004·Archives of Biochemistry and Biophysics·Jeremy P E SpencerCatherine Rice-Evans

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Citations

Apr 21, 2007·The British Journal of Nutrition·Simonetta GuarreraGiuseppe Matullo
Jan 29, 2008·Zygote : the Biology of Gametes and Early Embryos·C BadouardA Favier
Mar 18, 2008·Carcinogenesis·Fabrizio VegliaUNKNOWN Genair-EPIC Investigators
Oct 6, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Fulvio RicceriPaolo Vineis
Jan 27, 2009·Genes & Genetic Systems·Katsuaki NishinoTakemi Enomoto
Jan 29, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Natalia Bailón-MoscosoPatricia Ostrosky-Wegman
Jun 5, 2015·Chemical & Pharmaceutical Bulletin·Jee Hee SuhYoung Sik Cho
Sep 11, 2012·International Journal of Cancer. Journal International Du Cancer·David H Phillips, Stan Venitt
Sep 12, 2014·PloS One·Fulvio RicceriCarlotta Sacerdote

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