PMID: 15369422Sep 17, 2004Paper

Randomized controlled trial of a dose consolidation program

Journal of Managed Care Pharmacy : JMCP
Thomas DelateBrenda R Motheral

Abstract

To evaluate the effectiveness and financial impact of a drug dose consolidation (optimization) program using letter intervention. This pilot program in a large, mid-Atlantic health plan utilized a randomized controlled trial research design. A review of adjudicated pharmacy claims records was performed monthly for 3 consecutive months from November 2002 through February 2003 to identify inefficient (i.e., >once-daily) regimens for any one of 68 dosage strengths of 37 single-source maintenance drugs with once-daily dosing recommendations. Prescribers who had prescribed one or more inefficient regimens were identified and randomized to one of the 2 intervention arms or a control arm. Prescribers in both intervention arms were sent personalized letters with information on their patients. inefficient regimens and suggested dose consolidation options. Patients of prescribers in one intervention arm received a complementary, patient-oriented letter. Pharmacy claims for patients in all arms were examined at 180 days after the date of the letter mailing for conversion to an efficient (once-daily) regimen. Financial modeling analysis calculated net savings as changes in pharmacy expenditures minus administrative costs. A total of 2,614 ...Continue Reading

Citations

Jul 25, 2007·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Ties HoomansJohan L Severens
Oct 22, 2010·Clinical Pharmacology and Therapeutics·R S Epstein

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