Randomized Controlled Trial of Adjuvanted Versus Nonadjuvanted Influenza Vaccine in Kidney Transplant Recipients

Transplantation
Deepali KumarAtul Humar

Abstract

Influenza vaccine containing an oil-in-water emulsion adjuvant (MF-59) may lead to greater immunogenicity in organ transplant recipients. However, alloimmunization may be a concern with adjuvanted vaccines. We conducted a randomized trial comparing the safety and immunogenicity of adjuvanted versus nonadjuvanted influenza vaccine in adult kidney transplant patients. Patients were randomized 1:1 to receive 2012 to 2013 influenza vaccine with or without MF59 adjuvant. Preimmunization and postimmunization sera underwent strain-specific hemagglutination inhibition assay. HLA alloantibody was determined by Luminex single-antigen bead assay. We randomized 68 patients and 60 (29 nonadjuvanted; 31 adjuvanted) had complete samples available at follow-up. Seroconversion to at least 1 of 3 influenza antigens was present in 71.0% versus 55.2% in adjuvanted versus nonadjuvanted vaccine respectively (P = 0.21). Geometric mean titers and seroprotection rates were similar between groups. Seroconversion rates were especially low in those on MMF of 2 g or greater daily (44.4% vs 71.4%; P = 0.047). In the subgroup of patients 18 to 64 years old, seroconversion was significantly greater with adjuvanted vaccine (odds ratio, 6.10; 95% confidence int...Continue Reading

Associated Clinical Trials

References

Jun 1, 1997·European Journal of Epidemiology·J S Ellis, M C Zambon
Feb 7, 2002·The European Respiratory Journal·P J MazzoneJ R Maurer
May 2, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Joanne L BillingsChristine H Wendt
Jan 9, 2003·JAMA : the Journal of the American Medical Association·William W ThompsonKeiji Fukuda
Jan 22, 2003·Transplant Infectious Disease : an Official Journal of the Transplantation Society·R A VilchezS Kusne
Jul 15, 2003·Clinical Microbiology Reviews·Andrea DuchiniPaul J Pockros
Sep 16, 2004·JAMA : the Journal of the American Medical Association·William W ThompsonKeiji Fukuda
Jan 25, 2005·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Mary S HayneyRobert B Love
May 18, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Gaia MagnaniAngelo Branzi
May 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Janet E McElhaneyR Chris Bleackley
Dec 29, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J ScharpéW E Peetermans
Mar 18, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Michael G IsonLeo C Ginns
Feb 3, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kelly A BirdwellPeter F Wright
Aug 7, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S CandonL Chatenoud
Jan 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L Danzinger-IsakovUNKNOWN AST Infectious Diseases Community of Practice
Jul 14, 2010·The Lancet Infectious Diseases·Deepali KumarUNKNOWN American Society of Transplantation H1N1 Collaborative Study Group
Feb 4, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Oriol ManuelMatthias Cavassini
Mar 8, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Oriol ManuelDeepali Kumar
May 27, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Susanne BrakemeierKlemens Budde
Jun 16, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·I KaterinisJ Villard
Jun 16, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D Kumar, L Danziger-Isakov
Sep 13, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S A SchafferH J Ross
Oct 1, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D KumarUNKNOWN AST Infectious Diseases Community of Practice
May 1, 2012·Antiviral Therapy·Claire-Anne SiegristUNKNOWN H1N1 study group
Aug 14, 2012·Transplant Infectious Disease : an Official Journal of the Transplantation Society·M J C SallesC M Machado
Sep 25, 2012·Transplant Infectious Disease : an Official Journal of the Transplantation Society·T FairheadD Kumar
Feb 15, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A BaluchD Kumar
Apr 12, 2013·Immunologic Research·S Cerpa-CruzS Gutiérrez-Ureña

❮ Previous
Next ❯

Citations

Jul 13, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D KumarA Humar
Feb 28, 2018·Human Vaccines & Immunotherapeutics·Mohammad Bosaeed, Deepali Kumar
Dec 19, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pearlie P ChongDavid J Weber
May 18, 2018·Current Opinion in Infectious Diseases·Cédric Hirzel, Deepali Kumar
Sep 13, 2018·Pediatric Transplantation·Daniel E DulekNatasha B Halasa
Feb 5, 2019·Pediatric Transplantation·Megan CamerinoPriya Verghese
Feb 13, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Cedric HirzelUNKNOWN Influenza in Transplant Study Group
Jul 25, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anoma NelloreAjit P Limaye
Jan 8, 2020·Expert Review of Anti-infective Therapy·Matteo MombelliOriol Manuel
Jan 31, 2018·Transplantation·Raquel S B StucchiOriol Manuel
Oct 1, 2019·Current Opinion in Nephrology and Hypertension·Shilpa R Jain, Deepali Kumar
Sep 5, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Zaid HaddadinNatasha Halasa
Aug 8, 2020·Clinical Transplantation·Paolo CravediJamil Azzi
Dec 19, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Yoichiro NatoriDeepali Kumar
Mar 11, 2021·Current Transplantation Reports·Varun K PhadkeNadine G Rouphael
Oct 13, 2020·Transplantation·Tina M Marinelli, Deepali Kumar
May 25, 2021·Current Treatment Options in Infectious Diseases·Tara M Babu, Camille N Kotton
Dec 3, 2021·Expert Review of Anti-infective Therapy·Paraskevas FilippidisMatteo Mombelli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.