Randomized controlled trial of dietary creatine as an adjunct therapy to physical training in chronic obstructive pulmonary disease

American Journal of Respiratory and Critical Care Medicine
Sarah J DeaconM D L Morgan

Abstract

Skeletal muscle strength and bulk are reduced in patients with chronic obstructive pulmonary disease (COPD) and influence quality of life, survival, and utilization of health care resources. Exercise training during pulmonary rehabilitation (PR) can reverse some of these effects. In athletes and healthy elderly individuals, dietary creatine supplementation (CrS) has been shown to augment high-intensity exercise training, thereby increasing muscle mass. This article examines the effect of CrS on functional exercise capacity and muscle performance in people with COPD. One hundred subjects with COPD (mean [SD] age, 68.2 [8.2] yr; FEV(1), 44.0 [19.6] %predicted) were randomized to a double-blind, placebo-controlled, parallel group trial of CrS during 7 weeks of PR encompassing aerobic and resistance exercises. Subjects ingested creatine (22 g/d loading for 5 d; maintenance, 3.76 g/d throughout PR) or placebo. Baseline, postloading, and postrehabilitation measurements included pulmonary function, body composition, peripheral muscle strength, and functional performance (shuttle walking tests). A volunteer subgroup (n = 44) had pre- and postloading quadriceps muscle biopsies. Eighty subjects completed the trial (38 creatine, 42 placeb...Continue Reading

References

Nov 1, 1975·Scandinavian Journal of Clinical and Laboratory Investigation·J Bergstrom
Oct 1, 1992·The American Review of Respiratory Disease·K J KillianE J Campbell
Jun 1, 1995·International Journal of Sport Nutrition·P L Greenhaff
Apr 1, 1995·American Journal of Respiratory and Critical Care Medicine·R A GosselinkM L Decramer
May 1, 1994·The American Journal of Physiology·P L GreenhaffE Hultman
Jan 1, 1994·Journal of Clinical Epidemiology·E F JuniperL E Griffith
Jan 1, 1996·American Journal of Respiratory and Critical Care Medicine·F MaltaisP LeBlanc
Jul 1, 1996·Journal of Applied Physiology·E HultmanP L Greenhaff
Feb 14, 1998·Journal of Applied Physiology·K VandenbergheP Hespel
Nov 7, 1998·Acta Physiologica Scandinavica·S BermonC Dolisi
Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine·T M Hyers
Feb 22, 2000·International Journal of Sports Medicine·E S Rawson, P M Clarkson
May 5, 2000·Medicine and Science in Sports and Exercise·J D GilliamM H Trimble
Aug 2, 2000·The American Journal of Clinical Nutrition·A Casey, P L Greenhaff
Dec 12, 2001·Medicine and Science in Sports and Exercise·M J ChruschD G Burke
Mar 7, 2002·Medicine and Science in Sports and Exercise·Lincoln A GotshalkWilliam J Kraemer
May 10, 2002·The European Respiratory Journal·M C SteinerM D L Morgan
Nov 16, 2002·Journal of Applied Physiology·Steven L Nissen, Rick L Sharp
Feb 1, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Andrea BroseMark A Tarnopolsky
Apr 1, 2003·Journal of Applied Physiology·Bert O EijndePeter Hespel
Aug 30, 2003·International Journal of Sport Nutrition and Exercise Metabolism·J David Branch
Jun 29, 2004·The European Respiratory Journal·B R CelliUNKNOWN ATS/ERS Task Force
Feb 17, 2005·Journal of Cardiopulmonary Rehabilitation·Michael C SteinerMichael D L Morgan
Dec 15, 2005·American Journal of Physiology. Endocrinology and Metabolism·Harry R GoskerAnnemie M W J Schols

❮ Previous
Next ❯

Citations

Mar 3, 2009·Amino Acids·Bruno GualanoAntonio Herbert Lancha Junior
Aug 21, 2010·Journal of Cardiopulmonary Rehabilitation and Prevention·Priscila Games RoblesDina Brooks
Oct 19, 2012·Current Opinion in Clinical Nutrition and Metabolic Care·Coby van de BoolAnnemie M W J Schols
May 26, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Fahad Al-Ghimlas, David C Todd
Jul 25, 2008·American Journal of Respiratory and Critical Care Medicine·François MaltaisRichard Debigaré
Mar 26, 2009·American Journal of Respiratory and Critical Care Medicine·John D MaclayWilliam MacNee
Apr 20, 2013·Nutrients·Masayuki ItohKazutetsu Aoshiba
Aug 19, 2010·Oxidative Medicine and Cellular Longevity·Michael KingsleyJane McEneny
Mar 1, 2014·Medicine and Science in Sports and Exercise·Michaela C Devries, Stuart M Phillips
Nov 6, 2013·Endocrine·Darren G CandowScott C Forbes
Feb 23, 2013·Pulmonary Medicine·Benoit BorelFrançois Maltais
May 3, 2014·American Journal of Respiratory and Critical Care Medicine·François MaltaisUNKNOWN ATS/ERS Ad Hoc Committee on Limb Muscle Dysfunction in COPD
Dec 2, 2014·COPD·Esther Barreiro, Joaquim Gea
Jul 29, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Francine Maria AlmeidaRodolfo Paula Vieira
May 31, 2014·Clinics in Chest Medicine·Sally Singh
May 31, 2014·Clinics in Chest Medicine·Rachael A Evans, Michael D L Morgan
Jul 16, 2010·Journal of the American Medical Directors Association·John E MorleyUNKNOWN Society for Sarcopenia, Cachexia, and Wasting Disease
May 25, 2010·Primary Care·David Kilgore, Wadie Najm
Nov 28, 2012·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S GonemS Siddiqui
Feb 26, 2013·Respirology : Official Journal of the Asian Pacific Society of Respirology·Peter F CollinsRebecca J Stratton
Jun 15, 2015·Archivos de bronconeumología·Esther BarreiroJosé Miguel Rodríguez-González Moro
Nov 19, 2011·Chronic Respiratory Disease·Rachael A Evans
Mar 20, 2018·American Journal of Respiratory and Critical Care Medicine·Ariel Jaitovich, Esther Barreiro
Sep 23, 2014·The European Respiratory Journal·Annemie M ScholsSally J Singh
Jan 23, 2016·The European Respiratory Journal·Luis Puente-MaestuSusan Ward
Oct 13, 2016·ERJ Open Research·Carlos A CamilloThierry Troosters
Apr 20, 2012·The American Journal of Clinical Nutrition·Peter F CollinsMarinos Elia
Sep 2, 2011·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Fernando César WehrmeisterAna Maria Baptista Menezes
Feb 16, 2013·Journal of Applied Physiology·Fernanda RibeiroFrançois Maltais
Oct 25, 2017·American Journal of Respiratory and Critical Care Medicine·Raolat M AbdulaiStephen I Rennard
Feb 15, 2020·Chronic Respiratory Disease·Abdulelah M AldhahirSwapna Mandal
Aug 23, 2019·Journal of Functional Morphology and Kinesiology·Scott C ForbesKaelin C Young
Jun 3, 2021·Nutrients·Kylie K HarmonMatt S Stock

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.