Randomized controlled trial of dietary intervention: association between level of urinary phenolics and anti-mutagenicity

Mutation Research
Christian MalaveillePaolo Vineis

Abstract

We have undertaken a randomized trial to confirm the ability of a class of phenolics, flavonoids, to increase urinary anti-mutagenicity in smokers. Ninety heavy smokers were recruited and randomly assigned to three groups, who were given three different diets. One diet was rich in flavonoids, but not based on supplementation ('flavonoid'), one was a normal iso-caloric diet with an adequate administration of fruit and vegetables ('normal'), and one was based on supplementation of flavonoids in the form of green tea and soy products ('supplement'). The urinary anti-mutagenicity-as inhibiting effect of the urinary extracts on the mutations induced by MeIQx-was measured in Salmonella typhimurium YG1024 in the presence of liver S9 from male Sprague-Dawley rats treated with Aroclor 1254. The amount of total phenolics in the urinary extracts was measured by use of spectrometric analysis. We found that important dietary modifications can be achieved through special recipes and instructions given by a cook during an intensive course. The intervention was focused on increasing the flavonoid intake, and it was successful in that respect. In fact, differences in flavonoid intake were appreciated mainly between the first group (normal diet)...Continue Reading

Citations

Oct 25, 2008·Critical Reviews in Food Science and Nutrition·Gregory Tucker, Kevin Robards
Apr 21, 2006·Mutagenesis·Glenn TalaskaPaolo Vineis
Jul 28, 2015·Critical Reviews in Food Science and Nutrition·Yasmine Probst, Gail Zammit
Apr 21, 2007·The British Journal of Nutrition·Simonetta GuarreraGiuseppe Matullo
Nov 3, 2010·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Anoop KumarGabriele Sabbioni
Sep 17, 2021·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Takehiko Nohmi, Masahiko Watanabe

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.