Randomized controlled trial of docosahexaenoic acid supplementation in midwestern U.S. human milk donors.

Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine
Christina J ValentineLynette K Rogers

Abstract

Docosahexaenoic acid (DHA) is a long-chain polyunsaturated fatty acid important for neonatal neurodevelopment and immune homeostasis. Preterm infants fed donor milk from a Midwestern source receive only 20% of the intrauterine accretion of DHA. We tested the hypothesis that DHA supplementation of donor mothers would provide preterm infants with DHA intake equivalent to fetal accretion. After Institutional Review Board approval and informed consent, human milk donors to the Mother's Milk Bank of Ohio were randomized to receive 1 g of DHA (Martek(®) [now DSM Nutritional Lipids, Columbia, MD]) or placebo soy oil. Dietary intake data were collected and analyzed by a registered dietitian. Fatty acids were measured by gas chromatography/flame ionization detection. Statistical analysis used linear mixed models. Twenty-one mothers were randomly assigned to either the DHA group (n=10) or the placebo group (n=11). Donor age was a median of 31 years in both groups with a mean lactational stage of 19 weeks. Dietary intake of DHA at baseline in both groups was a median of 23 mg/day (range, 0-194 mg), significantly (p<0.0001) less than the minimum recommended intake of 200 mg/day. The DHA content of milk increased in the DHA-supplemented gro...Continue Reading

References

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Jul 7, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Alexandre Lapillonne, Craig L Jensen
Sep 21, 2010·The Journal of Pediatrics·Christina J ValentineLynette K Rogers
Oct 21, 2010·JAMA : the Journal of the American Medical Association·Maria MakridesUNKNOWN DOMInO Investigative Team

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Citations

Aug 19, 2015·The British Journal of Nutrition·Magdalena MucLotte Lauritzen
Dec 26, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Lynette K RogersSarah A Keim
Jun 21, 2017·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·M IacovouJ G Muir
Apr 1, 2018·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Kathleen CoppChristina J Valentine
Jul 15, 2015·The Cochrane Database of Systematic Reviews·Mario F Delgado-NogueraAssimina Galli-Tsinopoulou
Nov 28, 2018·The Cochrane Database of Systematic Reviews·Philippa MiddletonMaria Makrides
Apr 3, 2019·International Journal of Environmental Research and Public Health·Monika A ZielinskaAleksandra Wesolowska
May 7, 2019·Journal of Pediatric Gastroenterology and Nutrition·Christina J ValentineLynette K Rogers
Dec 15, 2017·Maternal Health, Neonatology and Perinatology·Stephanie L Smith, Christopher A Rouse
Feb 8, 2018·Ciência & saúde coletiva·Larissa Bueno FerreiraLuana Caroline Dos Santos
Feb 6, 2017·International Breastfeeding Journal·Brian A JuberMichelle L Baack
Feb 15, 2017·BMC Pregnancy and Childbirth·Susan E CarlsonCatalin S Buhimschi
Aug 20, 2019·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Isabell NesselSimon C Dyall

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Software Mentioned

CONSORT
Nutrition Data System for Research

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