Randomized controlled trial of gabapentin as an adjunct to perioperative analgesia in total hip arthroplasty patients

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
James PaulVictoria Avram

Abstract

Gabapentin was investigated as a single-dose adjunct to morphine for postoperative pain management. The primary objective was to determine if gabapentin given preoperatively and for two days postoperatively as part of multimodal analgesia would decrease postoperative morphine consumption in patients undergoing primary total hip arthroplasty (THA). The study group included 102 patients aged 19-90 years who were undergoing primary THA in a single joint with no contraindications to the study medications, no chronic pain syndrome, and no chronic opioid use. Intervention group patients (n = 48) received gabapentin 600 mg po preoperatively and 200 mg postoperatively on the day of surgery. They were continued on gabapentin at 200 mg three times daily for two days. Control group patients (n = 54) received placebo in a similar fashion. Preoperatively, all patients were given 30 mg of ketorolac intravenously and acetaminophen 1000 mg po. Postoperatively, they received intravenous patient-controlled analgesia with morphine, along with ketorolac 15 mg iv and acetaminophen 1000 mg po every six hours. The primary outcome was mean (SD) postoperative morphine consumption at 72 hr which was 55.8 (39.2) mg in the gabapentin groups vs 60.7 (37.2)...Continue Reading

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Citations

Nov 28, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Theodoros PapathanasiouTrine Meldgaard Lund
Apr 4, 2017·Pain Practice : the Official Journal of World Institute of Pain·Naveed T SiddiquiZeev Friedman
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Jul 8, 2021·The Journal of Bone and Joint Surgery. American Volume·Joseph A KaramJavad Parvizi
Nov 24, 2021·JAAPA : Official Journal of the American Academy of Physician Assistants·Meghan Migeon

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