PMID: 9523927Apr 2, 1998Paper

Randomized, controlled trial of inhaled budesonide as an adjunct to oral prednisone in acute asthma

Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine
L SungT P Klassen

Abstract

To compare the clinical effect of nebulized budesonide with placebo in acute pediatric asthma. A randomized, controlled, double-blind trial with parallel design was used in the ED of a tertiary care children's hospital. Children aged 6 months to 18 years with a moderate to severe exacerbation of asthma [Pulmonary Index Score (PIS) > or = 5 or < or = 11 after a salbutamol nebulization of 0.15 mg/kg] were eligible. All patients received prednisone 1 mg/kg orally and nebulized salbutamol (0.15 mg/kg) every 30 minutes for 3 doses and then every hour for 4 hours. The intervention was 2 mg (4 mL) of nebulized budesonide or 4 mL of nebulized normal saline. Baseline characteristics were comparable in the budesonide group (n = 24) and in the placebo group (n = 20). There were no significant differences in the primary outcome measure (PIS) between the 2 groups. However, the PIS at 1 hour had a tendency to be lower in the budesonide group (median = 5) as compared with the placebo group (median = 6; p = 0.07). Survival analysis of release/discharge from the ED/hospital showed a more rapid rate in the budesonide group as compared with the placebo group (p = 0.02). No adverse effects were seen. Although these preliminary results suggest that...Continue Reading

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Citations

Oct 3, 2002·Current Allergy and Asthma Reports·John C Carl, Carolyn M Kercsmar
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