Randomized Controlled Trial of Pulpotomy in Primary Molars using MTA and Formocresol Compared to 3Mixtatin: A Novel Biomaterial

The Journal of Clinical Pediatric Dentistry
Z JamaliS Shirazi

Abstract

This study was conducted to compare the efficacy of 3Mixtatin (a combination of simvastatin and 3Mix antibiotic) with MTA and Formocresol for the pulpotomy of primary molars. 114 children aged 3-6 years old with 150 primary molars were randomly allocated to three groups. MTA, Formocresol or 3Mixtatin were used for Pulpotomies. Hard setting zinc oxide eugenol was used to cover these materials. The teeth were restored with amalgam. Blinded radiographic and clinical examinations were conducted at 6, 12 and 24 months after treatment for the presence of pain, tenderness to palpation and percussion, sinus tract, swelling, presence of internal or external root resorption, inter-radicular radiolucency, and periapical lesion. 122 teeth were available for 24-month follow-up study. The overall success rate was 78.9% for FC, 90.5% for 3Mixtatin and 88.1% for MTA group. There was no significant difference in overall success rate among the groups after 24-month follow-up (X2=2.43, df = 2, P =0.27). Our findings demonstrated remarkable results of 3Mixtatin in pulpotomy of primary teeth at the 24-month follow-up. Therefore, 3Mixtatin may be considered as an effective material in pulpotomy of primary teeth because of its successful results.

References

Jan 1, 1992·International Endodontic Journal·E HoshinoK Kota
May 13, 1999·Journal of Endodontics·M Torabinejad, N Chivian
Jan 5, 2002·Calcified Tissue International·H OxlundT T Andreassen
Mar 18, 2006·Biomedical Research·Masao YoshinariTeruo Tanaka
May 26, 2006·Journal of Dental Research·K SakodaY Izumi
Mar 11, 2008·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Amir ShayeganAstrid Vanden Abbeele
Jun 6, 2008·The Journal of Clinical Pediatric Dentistry·Naser Asl AminabadiEsrafil Balayi Gajan
Jun 7, 2008·European Archives of Paediatric Dentistry : Official Journal of the European Academy of Paediatric Dentistry·F K Ng, L B Messer
Jun 24, 2008·Journal of Endodontics·Il-Young JungKenneth M Hargreaves
Sep 20, 2008·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Yasunori AyukawaKiyoshi Koyano
May 23, 2009·International Endodontic Journal·C RomaniaC Dandakis
May 7, 2013·International Journal of Health Geographics·Margaret O'Brien CaughyJames Murdoch
Jan 1, 2012·International Journal of Clinical Pediatric Dentistry·N Ratnakumari, Bijimol Thomas
Sep 16, 2015·International Journal of Paediatric Dentistry·Naser Asl AminabadiSajjad Shirazi
Nov 23, 2015·European Archives of Paediatric Dentistry : Official Journal of the European Academy of Paediatric Dentistry·N A AminabadiS Shirazi
Dec 29, 2015·European Journal of Oral Sciences·Naser A AminabadiSajjad Shirazi
Mar 24, 2017·Clinical Oral Investigations·Naser Asl AminabadiSajjad Shirazi

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Citations

Mar 25, 2020·Journal of Clinical Medicine·Maurizio BossùStefano Di Carlo
Feb 13, 2021·Journal of Dental Research, Dental Clinics, Dental Prospects·Naser Asl AminabadiSajjad Shirazi
Jun 5, 2021·Acta Odontologica Scandinavica·Battsetseg TseveenjavLeo Tjäderhane
Aug 28, 2021·Journal of Pharmacy & Bioallied Sciences·Shruti JhaRitu Namdev
Nov 10, 2021·Acta Odontologica Scandinavica·Gökçe Çiçek IldeşAli Mentes

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