Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis

The Journal of Dermatological Treatment
Mohammad Hassan JavanbakhtAbbas Mirshafiey

Abstract

Atopic dermatitis is a chronically relapsing, highly pruritic and inflammatory skin disease. This study was done to assess the effects of vitamins D and E supplementation on the clinical manifestation of atopic dermatitis. Forty-five atopic dermatitis patients were included in a randomized, double-blind, placebo-controlled trial. They were randomly divided into four groups and treated for 60 days: group P (n = 11), vitamins D and E placebos; group D (n = 12), 1600 IU vitamin D(3) plus vitamin E placebo; group E (n = 11), 600 IU synthetic all-rac-α-tocopherol plus vitamin D placebo; and group DE (n = 11), 1600 IU vitamin D(3) plus 600 IU synthetic all-rac-α-tocopherol. Serum 25(OH) vitamin D and plasma α-tocopherol were determined before and after the trial. The clinical improvement was evaluated with SCORing Atopic Dermatitis (SCORAD). Data were analyzed by analysis of variance (ANOVA) and Kruskal-Wallis tests. SCORAD was reduced after 60 days in groups D, E and DE by 34.8%, 35.7% and 64.3%, respectively (p = 0.004). Objective SCORAD also showed significant improvement. There was a positive correlation between SCORAD and intensity, objective, subjective and extent (p < 0.001). We found a significant negative association between...Continue Reading

References

Jan 1, 1993·Dermatology : International Journal for Clinical and Investigative Dermatology
Sep 1, 1996·International Archives of Allergy and Immunology·I KatayamaK Nishioka
Jan 1, 1997·Dermatology : International Journal for Clinical and Investigative Dermatology·B KunzA Taïeb
Nov 15, 2000·Lancet·A FogartyJ Britton
Jan 18, 2003·Lancet·Donald Y M Leung, Thomas Bieber
Mar 26, 2004·Archives of Dermatological Research·Petra De HaesSiegfried Segaert
Jul 13, 2004·Allergy·E J O'Connell
Jan 25, 2005·Journal of Photochemistry and Photobiology. B, Biology·Petra De HaesSiegfried Segaert
Jun 9, 2005·The Journal of Allergy and Clinical Immunology·Graham Devereux, Anthony Seaton
Nov 18, 2005·European Journal of Gastroenterology & Hepatology·Kirsi Laitinen, Erika Isolauri
Nov 1, 2006·Allergy·G ByremoK H Carlsen
Jun 20, 2007·Experimental Dermatology·Jörg Reichrath
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Aug 28, 2007·Molecular Aspects of Medicine·Jens J Thiele, Swarna Ekanayake-Mudiyanselage
Mar 28, 2008·The British Journal of Dermatology·K VähävihuE Snellman
Nov 19, 2008·The Journal of Allergy and Clinical Immunology·Tissa R HataRichard L Gallo

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Citations

Sep 11, 2012·Pediatric Dermatology·Krishna Mutgi, John Koo
Jan 30, 2014·Anais Brasileiros De Dermatologia·Kleyton de Carvalho MesquitaIzelda Maria Carvalho Costa
Apr 8, 2014·Annales de dermatologie et de vénéréologie·S RoncerayC Droitcourt
Jan 28, 2014·American Journal of Clinical Dermatology·Jonathan I Silverberg
Jan 18, 2013·The Veterinary Quarterly·Alja Plevnik KapunTina Kotnik
Mar 6, 2012·The Journal of Dermatological Treatment·Ad Tsakok
Aug 22, 2015·The Journal of Dermatological Treatment·Ilteris Oguz TopalSembol Yıldırmak
Aug 5, 2015·Journal of Clinical Medicine·Debra J Palmer
Feb 11, 2016·Pediatric Dermatology·Renata RoblVânia Oliveira Carvalho
Apr 12, 2016·Nutrition·Gaeun Kim, Ji-Hyun Bae
Feb 5, 2013·The Journal of Allergy and Clinical Immunology·Lynda SchneiderDana Wallace
Feb 19, 2013·Journal of the American Academy of Dermatology·Yvonne E ChiuBeth A Drolet
Dec 30, 2015·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Thomas WerfelUNKNOWN Association of Scientific Medical Societies of Germany
Feb 19, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M S de Bruin WellerC A F M Bruijnzeel-Koomen
Jan 5, 2014·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Susan Shuxin WangTing Fan Leung
May 4, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·T R HataR L Gallo
Mar 24, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·A WollenbergUNKNOWN European Task Force on Atopic Dermatitis/EADV Eczema Task Force
Sep 30, 2014·Journal of the American Academy of Dermatology·Robert SidburyLawrence F Eichenfield
Nov 8, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A P JonesS L Prescott
Jan 13, 2015·Photodermatology, Photoimmunology & Photomedicine·Rebecca F RoseVictoria Goulden
Mar 26, 2016·Expert Review of Clinical Immunology·Shannon K QuirkDevendra K Agrawal
Aug 11, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Allison L Goddard, Peter A Lio
May 15, 2015·Journal of Immunology Research·Michelangelo VestitaDomenico Bonamonte
Feb 12, 2014·Dermato-endocrinology·Uwe GröberMichael F Holick
Apr 15, 2015·Clinical Reviews in Allergy & Immunology·Melanie Chong, Luz Fonacier
Oct 6, 2014·The Journal of Allergy and Clinical Immunology·Carlos A CamargoB Khandsuren
Sep 18, 2016·Clinics in Dermatology·Asta JuzenieneWilliam B Grant
Sep 13, 2016·Journal of the American Academy of Dermatology·Mary K HillCory A Dunnick
Mar 18, 2016·Anais Brasileiros De Dermatologia·Kleyton de Carvalho MesquitaIzelda Maria Carvalho Costa
Apr 2, 2015·Anais Brasileiros De Dermatologia·Ana Paula Dornelles da Silva Manzoni, Magda Blessmann Weber
Sep 2, 2017·Chinese Journal of Integrative Medicine·George ManMao-Qiang Man
Jun 1, 2018·International Journal of Molecular Sciences·Meenakshi UmarAouatef I Chouchane
Jan 15, 2014·The Cochrane Database of Systematic Reviews·Goran BjelakovicChristian Gluud
Sep 22, 2018·International Journal of Dermatology·Karen Sánchez-ArmendárizJudith Domínguez-Cherit
Jul 3, 2013·Allergy, Asthma & Immunology Research·Jae-Won Oh
May 3, 2013·Allergy, Asthma & Immunology Research·Elisabeth RoiderJürgen Schauber
Feb 27, 2016·F1000Research·Michael Barton, Robert Sidbury
Oct 20, 2018·Journal of Cutaneous Medicine and Surgery·Irene Lara-CorralesElena Pope

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Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

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