Randomized dose-comparison studies of intravitreous fomivirsen for treatment of cytomegalovirus retinitis that has reactivated or is persistently active despite other therapies in patients with AIDS

American Journal of Ophthalmology
Vitravene Study Group

Abstract

To compare the efficacy of two regimens of intravitreous fomivirsen for treatment of cytomegalovirus (CMV) retinitis that had reactivated or was persistently active despite other anti-CMV therapies in patients with acquired immunodeficiency syndrome (AIDS). Randomized treatment intervention clinical trials. Two multicenter prospective randomized open-label controlled clinical trials (USA/Brazilian study; EuroCanadian study) each compared two treatment regimens of intravitreous fomivirsen (330 microg/injection), a more intense schedule (regimen A) consisting of 3 weekly injections as induction, followed by injections every 2 weeks as maintenance therapy, and a less intense schedule (regimen B), consisting of two injections at day 1 and day 15 as induction, followed by injections every 4 weeks as maintenance therapy. A total of 61 patients (67 eyes) were treated with regimen A and a total of 32 patients (39 eyes) were treated with regimen B. Time to progression was determined by masked evaluation of serial fundus photographs. The proportion of patients whose lesions became less active or inactive is described for the USA/Brazilian study as an additional measure of efficacy. Results were similar for both regimens. In the USA/Brazi...Continue Reading

References

Jul 1, 1987·Ophthalmology·G N HollandR E Champlin
Apr 3, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·J P LalezariH S Jaffe

❮ Previous
Next ❯

Citations

Aug 20, 2008·Indian Journal of Ophthalmology·John H Kempen
Jun 4, 2005·Clinical & Experimental Ophthalmology·Weng T Ng, Patrick Versace
Jul 15, 2016·RNA Biology·Philipp ReautschnigThorsten Stafforst
Nov 30, 2004·The Lancet Infectious Diseases·Maher K Gandhi, Rajiv Khanna
Apr 21, 2005·MMWR. Recommendations and Reports : Morbidity and Mortality Weekly Report. Recommendations and Reports·Constance A BensonUNKNOWN Infectious Diseases Society of America
Nov 11, 2006·Advanced Drug Delivery Reviews·C BloquelF Behar-Cohen
Oct 20, 2004·Retina·Rama D JagerEmmett T Cunningham
Aug 4, 2005·Retina·Daniel E GoldbergWilliam R Freeman
Mar 16, 2017·EMBO Molecular Medicine·Caroline GodfreyVirginia Arechavala-Gomeza
Dec 11, 2007·Nature Biotechnology·Joost HaasnootBen Berkhout
Nov 21, 2002·Current Opinion in Ophthalmology·Haroldo V Moraes
Apr 26, 2016·British Journal of Clinical Pharmacology·Kannan Sridharan, Nithya Jaideep Gogtay
Oct 15, 2019·Frontiers in Genetics·Alireza ShahryariHeiko Lickert
Mar 26, 2021·Nature Reviews. Drug Discovery·Stanley T CrookeXue-Hai Liang
May 20, 2021·Seminars in Ophthalmology·Kevin FerenchakRachel Huckfeldt
Jun 5, 2003·Pharmacology & Therapeutics·Santo LandolfoDavid Lembo
Sep 24, 2004·Trends in Pharmacological Sciences·Scott P HenryNicholas M Dean
Jan 13, 2018·Chemical Reviews·Alicia J AngelbelloMatthew D Disney

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.