Randomized, double-blind comparison of ondansetron versus ondansetron plus metopimazine as antiemetic prophylaxis during platinum-based chemotherapy in patients with cancer

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
J HerrstedtP Dombernowsky

Abstract

To investigate the antiemetic effect and tolerability of the 5-hydroxytryptamine3(5-HT3) antagonist ondansetron plus the dopamine D2 antagonist metopimazine versus ondansetron alone in patients receiving platinum-based chemotherapy. One hundred eleven chemotherapy-naive patients who were scheduled to receive two consecutive courses of platinum-based chemotherapy were randomized between ondansetron 8 mg intravenously (IV) followed by 8 mg orally twice a day plus metopimazine 35 mg/m2 as a 24-hour continuous infusion followed by 30 mg orally four times a day for 4 days, or ondansetron plus placebo. The study used a double-blind, crossover, placebo-controlled design. Ninety-four patients completed the crossover. Complete response (CR; no emetic episodes) was obtained on day 1 in 77.7% of the patients who received the combination versus 50.0% of those who received ondansetron alone (P = .00002), and in 51.7% versus 31.0% on days 2 to 6 (P = .0009). The overall CR (days 1 to 6) was 48.9% versus 25.3% (P = .0002). Additionally, significantly less nausea was observed with the combination on day 1 (P = .0002), days 2 to 6 (P = .0001), and days 1 to 6 (P = .00004). Patient preference was 63.6% for the combination and 13.6% for ondansetr...Continue Reading

Citations

Aug 26, 2014·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Thaiana Aragão SantanaAuro Del Giglio
Nov 10, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·J HerrstedtP Dombernowsky
Dec 22, 2007·Nature Clinical Practice. Oncology·Jørn Herrstedt
Jul 30, 2005·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·P C NathanB M Feldman
Aug 19, 2007·Basic & Clinical Pharmacology & Toxicology·Jørn Herrstedt, Per Dombernowsky
Aug 13, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Jørn HerrstedtAlexander Molassiotis
Apr 3, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T SigsgaardP Dombernowsky
Nov 30, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·J HerrstedtG M Fox

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