Randomized double-blind comparison of the effects of intramyometrial and intravenous oxytocin during elective cesarean section

The Journal of Obstetrics and Gynaecology Research
Chieko AkinagaKatsuo Terui

Abstract

Obstetricians sometimes administer intramyometrial oxytocin to stimulate uterine contraction during cesarean section, but its effects have not been well investigated. We performed a randomized, double-blind study to test the hypothesis that a small dose of intramyometrial oxytocin would induce acceptable uterine contractility more quickly and with fewer hemodynamic side-effects than the same dose administered intravenously. Forty women with a single fetus at ≥36 weeks of gestational age scheduled for elective cesarean section under spinal anesthesia were randomized to the intravenous and intramyometrial groups to receive oxytocin at 0.07 IU/kg. The drug was administered immediately after umbilical cord clamping. Systolic blood pressure, heart rate, intraoperative blood loss, uterine tone, total amount of intraoperative oxytocin, and additional uterotonic drugs administered in the first 24 h were compared. Maximum uterine contractility was achieved after 2 and 10 min for the intravenous and intramyometrial groups, respectively. The mean hemodynamic parameters of the intramyometrial group were stable. In contrast, the intravenous group showed a reduction in systolic blood pressure after 2-4 min and increased heart rate after 1-2 ...Continue Reading

References

Aug 26, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·K C DennehyJ P Sylvain
Nov 2, 2004·Obstetrics and Gynecology·José C A CarvalhoRory Windrim
Jan 6, 2006·Obstetrics and Gynecology·Mrinalini BalkiJosé C A Carvalho
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Citations

Apr 26, 2018·The Cochrane Database of Systematic Reviews·Ioannis D GallosArri Coomarasamy
Dec 21, 2018·The Cochrane Database of Systematic Reviews·Ioannis D GallosArri Coomarasamy
May 2, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ahmed A AbdelaleemIhab H El-Nashar
Jul 28, 2019·Anaesthesia·D T Monks, A Palanisamy
Mar 3, 2021·American Journal of Obstetrics & Gynecology MFM·Naida M ColeMichaela K Farber

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