Randomized, double-blind, placebo-controlled study of the abuse potential of different formulations of oral oxycodone

Pain Medicine : the Official Journal of the American Academy of Pain Medicine
Lynn R WebsterGregory J Stoddard

Abstract

The objective of this study was to evaluate the pharmacokinetics and abuse potential of different formulations of oxycodone. The participants completed an 8-day, placebo-controlled trial with four phases: naloxone challenge, double-blind drug discrimination, double-blind abuse liability, and discontinuation. Nineteen healthy, male, recreational drug abusers participated in this study. The participants were administered different doses and formulations of oxycodone (40 mg immediate release [IR], 40 mg controlled release [CR], crushed 40 mg CR, and 80 mg CR) to evaluate pharmacokinetic parameters and ratings of drug liking and high. Pharmacokinetic parameters were determined over a 12-hour dosing interval. The primary pharmacodynamic endpoints were two questions from the Drug Effects Questionnaire ("Do you like the drug?" and "How high are you now?"). Maximal plasma concentrations and area under the curve determinations were similar for 40 mg IR, crushed 40 mg CR, and 80 mg CR, which were all greater than 40 mg CR. For drug liking and high, the maximal effect and area under the effect curve were similar for the three formulations, which were all greater than 40 mg CR. The dose required to produce comparable reports of drug liking...Continue Reading

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Citations

Oct 16, 2013·Peptides·Richard J Bodnar
Dec 29, 2012·Psychopharmacology·Meghan E MoreanStephanie S O'Malley
Oct 26, 2012·Postgraduate Medicine·Marco Pappagallo, Marta Sokolowska
Jul 7, 2015·Drug Development and Industrial Pharmacy·Tiffani D EisenhauerThomas Barrett
Jul 25, 2015·Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists·Joseph V PergolizziJack E Henningfield
Aug 26, 2015·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Terri L MortonLynn Webster
Mar 13, 2014·Acta Anaesthesiologica Scandinavica·L PedersenO M S Fredheim
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Jun 23, 2016·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Mona DarwishLynn R Webster
Jul 23, 2016·Journal of Clinical Pharmacology·Beatrice SetnikLynn Webster
Sep 4, 2018·Expert Opinion on Drug Discovery·Joseph V PergolizziRobert B Raffa
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Sep 26, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Xue GeMichael A Eldon
Mar 25, 2017·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Lynn WebsterMichael A Eldon
Feb 29, 2020·Cellular and Molecular Neurobiology·Caroline M KopruszinskiFrank Porreca
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Nov 2, 2016·Journal of Clinical Pharmacology·Ernest A KopeckyEdward M Sellers
Nov 28, 2020·Cellular and Molecular Neurobiology·Cherkaouia KibalyCatherine M Cahill

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