Randomized, double-blind, placebo-controlled trial of oral albuterol in infants with mild-to-moderate acute viral bronchiolitis

The Journal of Pediatrics
Hema PatelRobert W Platt

Abstract

To determine whether oral albuterol is effective in reducing symptomatology of acute viral bronchiolitis in infants with mild-to-moderate illness. In a randomized, double-blind trial, previously well infants were randomized upon discharge from the emergency department to receive either albuterol (0.1 mg/kg/dose) three times per day or placebo three times per day for 7 days. Daily standardized telephone interviews were conducted for as long as 14 days. The primary outcome was the time to resolution of illness. Secondary outcomes included time to normal feeding, normal sleeping, quiet breathing, resolved cough, and coryza. We studied 129 infants (albuterol, n = 64; placebo, n = 65). Baseline characteristics were similar between groups. The overall mean age was 5.3 months, 60% were male, and 49 of 61 tested infants were positive for respiratory syncytial virus. The median (95% confidence interval) time to resolution of illness (days) was similar: albuterol, 9.0 (8-13); placebo, 8.0 (7-9); P =.3) (log-rank test). There were no significant group differences in any secondary outcome. Health care revisit and admission rates were similar between groups. No significant group differences in either primary or secondary outcomes in infants...Continue Reading

Citations

May 15, 2009·The New England Journal of Medicine·Amy C PlintUNKNOWN Pediatric Emergency Research Canada (PERC)
Dec 18, 2013·BMJ : British Medical Journal·Matthew ThompsonUNKNOWN TARGET Programme Team
Jun 17, 2006·American Journal of Respiratory Cell and Molecular Biology·David Proud, Chung-Wai Chow
Oct 23, 2008·The Pediatric Infectious Disease Journal·James E Gern
Mar 22, 2016·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Jeffrey Baron, Gladys El-Chaar
May 19, 2009·Clinical Pediatrics·Scott A LorchGabriel J Escobar
Jan 20, 2004·The Pediatric Infectious Disease Journal·James E Gern
Apr 6, 2004·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Amy C PlintTerry P Klassen
Jun 18, 2014·The Cochrane Database of Systematic Reviews·Anne M Gadomski, Melissa B Scribani
Sep 4, 2004·Indian Journal of Pediatrics·G R Sethi, Gaurav Nagar
Apr 14, 2010·Pediatric Emergency Care·Frank D Petruzella, Marc H Gorelick
Nov 14, 2013·Indian Pediatrics·Nishant VermaS K Kabra
Feb 6, 2004·Current Opinion in Pediatrics·Jean E Klig
Jan 22, 2005·Current Opinion in Pediatrics·Richard J Scarfone
Dec 22, 2010·Expert Review of Anti-infective Therapy·Leonard R Krilov
Apr 1, 2009·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Lea S Eiland
Apr 5, 2005·Pediatrics·Dimitri A ChristakisDanielle M Zerr
Oct 29, 2014·Pediatrics·Shawn L RalstonSinsi Hernandez-Cancio
Sep 30, 2010·Pediatrics·Amanda SumnerUNKNOWN Pediatric Emergency Research Canada

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