Randomized, double-blind, placebo-controlled trial of the once-daily GLP-1 receptor agonist lixisenatide in Asian patients with type 2 diabetes insufficiently controlled on basal insulin with or without a sulfonylurea (GetGoal-L-Asia).

Diabetes, Obesity & Metabolism
Y SeinoEFC10887 GETGOAL-L Asia Study Investigators

Abstract

To assess the efficacy and safety of once-daily lixisenatide versus placebo in Asian patients with type 2 diabetes insufficiently controlled on basal insulin ± sulfonylurea. In this 24-week, randomized, double-blind, placebo-controlled, parallel-group, multicentre study, participants (mean baseline HbA(1c) 8.53%) from Japan, Republic of Korea, Taiwan and the Philippines received lixisenatide (n = 154) or placebo (n = 157) in a stepwise dose increase to 20 µg once daily. The primary endpoint was HbA(1c) change from baseline to week 24. Once-daily lixisenatide significantly improved HbA(1c) versus placebo (LS mean difference vs. placebo = -0.88% [95%CI= -1.116, -0.650]; p < 0.0001), and allowed more patients to achieve HbA(1c) <7.0% (35.6 vs. 5.2%) and ≤ 6.5% (17.8 vs. 1.3%). Lixisenatide also significantly improved 2-h postprandial plasma glucose and glucose excursion, average 7-point self-monitored blood glucose and fasting plasma glucose. Lixisenatide was well tolerated; 86% of patients on lixisenatide completed the study versus 92% on placebo. Ten (6.5%) lixisenatide and 9 (5.7%) placebo patients experienced serious adverse events. More lixisenatide patients [14 (9.1%)] discontinued for adverse events versus placebo [5 (3.2%)...Continue Reading

References

Sep 25, 2008·The Journal of Clinical Endocrinology and Metabolism·Jessica E MatthewsUNKNOWN Albiglutide Study Group
Dec 3, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·A Ceriello, S Colagiuri
Oct 28, 2009·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Helena W RodbardStanley S Schwartz
Aug 19, 2010·International Journal of Clinical Practice·D Russell-Jones
Apr 22, 2010·Journal of Diabetes Investigation·Yutaka SeinoDaisuke Yabe

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Citations

Feb 21, 2013·Advances in Therapy·Michael HorowitzKaren L Jones
Aug 7, 2013·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Lesley J Scott
Apr 6, 2013·Drugs·Shelley Elkinson, Gillian M Keating
Sep 10, 2013·Cardiovascular Diabetology·John R Petrie
Dec 24, 2013·Drug Design, Development and Therapy·Dominique Xavier BrownMarc Evans
Dec 11, 2013·The Journal of Endocrinology·L van BloemendaalM Diamant
Apr 4, 2014·European Journal of Internal Medicine·Asger LundTina Vilsbøll
Oct 4, 2013·Expert Opinion on Pharmacotherapy·Thomas Forst, Andreas Pfützner
Jun 17, 2015·Expert Opinion on Pharmacotherapy·Carla Francés ArtigasMichael J Theodorakis
Nov 18, 2015·Expert Review of Clinical Pharmacology·L ØstergaardS Madsbad
Jan 7, 2016·Expert Review of Clinical Pharmacology·Awadhesh Kumar Singh, Ritu Singh
Aug 15, 2014·Expert Opinion on Drug Discovery·Mikkel ChristensenFilip K Knop
Mar 17, 2015·Current Medical Research and Opinion·Keith C Ferdinand, Samar A Nasser
Oct 11, 2013·Current Medical Research and Opinion·Ronald Goldenberg
Aug 7, 2013·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Pedro Mezquita-RayaUNKNOWN Diabetes Mellitus Working Group of the Spanish Society of Endocrinology and Nutrition (SEEN)
Nov 15, 2015·International Journal of Clinical Practice·T ReidA Rhinehart
Oct 20, 2012·Annales d'endocrinologie·Thomas CunyBertrand Cariou
Feb 24, 2016·Indian Journal of Endocrinology and Metabolism·Awadhesh Kumar Singh, Ritu Singh
Aug 27, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Charles ShaeferAndres DiGenio
Mar 26, 2016·Journal of the American College of Cardiology·Greer WaldropSanjay Rajagopalan
Mar 17, 2015·Diabetes/metabolism Research and Reviews·Reinhard H A BeckerFranck Pellissier
Nov 11, 2014·Pharmacotherapy·Jennifer M Trujillo, Wesley Nuffer

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