Randomized, Double-Blind, Placebo-Controlled Trial of the Effect of Vitamin D3 on the Interferon Signature in Patients With Systemic Lupus Erythematosus

Arthritis & Rheumatology
Cynthia AranowBetty Diamond

Abstract

Vitamin D modulates the immune response and blocks induction of an interferon (IFN) signature by systemic lupus erythematosus (SLE) sera. This study was undertaken to investigate the effects of vitamin D supplementation on the IFN signature in patients with SLE. SLE patients (n = 57) with stable, inactive disease, a serum 25-hydroxyvitamin D (25[OH]D) level ≤20 ng/ml, an elevated anti-double-stranded DNA antibody level, and an IFN signature (as determined by measuring the expression levels of 3 IFN response genes) were randomized into a 12-week double-blind, placebo-controlled trial of vitamin D3 at doses of 2,000 IU or 4,000 IU. An IFN signature response was defined as a 50% reduction in the expression of 1 of the 3 genes or a 25% reduction in the expression of 2 of the 3 genes. Disease activity, adverse events, and endocrine effects were assessed. Baseline characteristics of the patients in the 3 treatment groups (placebo, low-dose vitamin D3 , or high-dose vitamin D3 ) were similar. Repletion of 25(OH)D (i.e., levels ≥30 ng/ml) was not observed in any of the patients who were receiving placebo, while repletion was observed in 16 of 33 patients receiving vitamin D3 . The percentage of patients with an IFN signature response d...Continue Reading

References

Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
May 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T NakaseK Takaoka
Apr 26, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·L PiemontiV Di Carlo
Apr 5, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M Linker-IsraeliH P Koeffler
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Feb 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Emily C BaechlerTimothy W Behrens
Dec 14, 2004·Arthritis and Rheumatism·Kyriakos A KirouMary K Crow
Dec 16, 2005·The New England Journal of Medicine·Michelle PetriUNKNOWN OC-SELENA Trial
Jul 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sheng ChenPeter E Lipsky
Jul 3, 2008·Nature Clinical Practice. Rheumatology·Luciano Adorini, Giuseppe Penna
Jul 30, 2008·Current Rheumatology Reports·Diane L Kamen, Cynthia Aranow
Apr 30, 2011·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Cynthia Aranow
Jul 24, 2013·Journal of Translational Medicine·Samar OjaimiKumar Visvanathan

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Citations

Nov 4, 2015·Frontiers in Immunology·Mirentxu IruretagoyenaPaula Isabel Burgos
May 15, 2016·Rheumatology·John A Reynolds, Ian N Bruce
Nov 2, 2016·Scandinavian Journal of Rheumatology·Y RosenY Shoenfeld
Apr 13, 2018·Critical Reviews in Food Science and Nutrition·Marília Cristina Santos de MedeirosMaria Irany Knackfuss
Sep 27, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Li ChenHaidong Zhu
Jul 10, 2019·Calcified Tissue International·Stephanie R HarrisonMartin Hewison
Oct 10, 2019·International Journal of Rheumatic Diseases·Mario García-CarrascoAlejandro Ruiz-Arguelles
Oct 9, 2019·Lupus Science & Medicine·Sara K TedeschiKaren H Costenbader
Jun 13, 2017·Pharmacology Research & Perspectives·Yat Yee WongLauren A Trepanier
Jan 12, 2017·Journal of Immunology Research·Sang Jin LeeYeong Wook Song
May 6, 2017·Nature Medicine·Carl H JuneJeffrey A Bluestone
Feb 24, 2017·Immunologic Research·António MarinhoCarlos Vasconcelos
Feb 7, 2017·Frontiers in Immunology·Wendy DankersErik Lubberts
May 1, 2020·Nutrients·Geneviève Mailhot, John H White
Jul 20, 2019·Autoimmunity Reviews·Giuseppe MurdacaSebastiano Gangemi
Jan 14, 2021·Biology of Sex Differences·Maria Luisa DupuisElena Ortona

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