Randomized, double-blind placebo-controlled trial to evaluate the safety and immunogenicity of combined Salmonella typhi Ty21a and Vibrio cholerae CVD 103-HgR live oral vaccines.

Infection and Immunity
H KollaritschS J Cryz

Abstract

Healthy adults (n=330) were randomized to receive either a bivalent vaccine composed of Vibrio cholerae CVD 103-HgR and Salmonella typhi Ty21a or a placebo. The combined vaccine was well tolerated. Approximately 80% of vaccines manifested a significant rise in anti-S. typhi immunoglobulin G or immunoglobulin A lipopolysaccharide antibody levels. Significant (fourfold or greater) rises in anti-Inaba or anti-Ogawa vibriocidal antibody titer were achieved by 94 and 80% of vaccine recipients, respectively. Elevated baseline vibriocidal antibody titers showed a modest suppressive effect on the rate of seroconversion.

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Citations

Oct 25, 2000·Journal of Pediatric Gastroenterology and Nutrition·M M Levine
Mar 18, 2011·The Cochrane Database of Systematic Reviews·David SinclairPatricia M Graves
Aug 1, 2015·Future Microbiology·Sarah S Jackson, Wilbur H Chen
Apr 4, 2001·Journal of Travel Medicine·E T Ryan, S B Calderwood
Nov 5, 2002·FEMS Microbiology Reviews·Helen S GarmoryRichard W Titball
May 12, 2017·MMWR. Morbidity and Mortality Weekly Report·Karen K WongArthur L Reingold
Oct 21, 2004·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Mark A FletcherPierre Saliou
Nov 16, 2021·Expert Review of Vaccines·James McCartyDouglas Haney

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