Randomized double-blind placebo-controlled crossover study of caffeine in patients with intermittent claudication

The British Journal of Surgery
A H MomsenJ S Lindholt

Abstract

Intermittent claudication is a disabling symptom of peripheral arterial disease for which few medical treatments are available. This study investigated the effect of caffeine on physical capacity in patients with intermittent claudication. This randomized double-blind placebo-controlled crossover study included 88 patients recruited by surgeons from outpatient clinics. The participants abstained from caffeine for 48 h before each test and then received either a placebo or oral caffeine (6 mg/kg). After 75 min, pain-free and maximal walking distance on a treadmill, perceived pain, reaction times, postural stability, maximal isometric knee extension strength, submaximal knee extension endurance and cognitive function were measured. The analysis was by intention to treat. Caffeine increased the pain-free walking distance by 20.0 (95 per cent confidence interval 3.7 to 38.8) per cent (P = 0.014), maximal walking distance by 26.6 (12.1 to 43.0) per cent (P < 0.001), muscle strength by 9.8 (3.0 to 17.0) per cent (P = 0.005) and endurance by 21.4 (1.2 to 45.7) per cent (P = 0.004). However, postural stability was reduced significantly, by 22.1 (11.7 to 33.4) per cent with eyes open (P < 0.001) and by 21.8 (7.6 to 37.8) per cent with e...Continue Reading

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References

Dec 31, 1975·Psychopharmacologia·H M FranksG A Starmer
Jan 1, 1992·European Journal of Applied Physiology and Occupational Physiology·F AnselmeC Prefaut
Jan 1, 1989·European Journal of Applied Physiology and Occupational Physiology·B FalkY Shapiro
Jun 1, 1981·Clinical Physiology·B Berglund, B Eklund
Dec 24, 1997·Journal of the American Geriatrics Society·T RantanenE Heikkinen
Jul 3, 1998·Clinical Physiology·T PeräkyläM Lepäntalo
Oct 7, 1998·Journal of Applied Physiology·M H Van Soeren, T E Graham
Apr 7, 1999·VASA. Zeitschrift für Gefässkrankheiten·U Müller-BühlA Wiesemann
Sep 19, 2001·JAMA : the Journal of the American Medical Association·A T HirschW R Hiatt
Oct 5, 2001·Sports Medicine·T E Graham
Jun 19, 2002·Annals of Internal Medicine·Mary McGrae McDermottElizabeth Clark
May 1, 1965·The Journal of Nervous and Mental Disease·O SPREEN, A L BENTON
Oct 30, 2004·Medicine and Science in Sports and Exercise·Irena ZwierskaJohn M Saxton
Jan 16, 2007·Journal of Vascular Surgery·L NorgrenUNKNOWN TASC II Working Group
Dec 18, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Terry E GrahamFarah S L Thong
Jul 10, 2009·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A H MomsenJ S Lindholt

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Citations

Nov 7, 2013·Nutritional Neuroscience·Michael J DuncanDominic Langdon
Dec 4, 2014·The Journal of Nutrition, Health & Aging·M J DuncanS Leddington Wright
Feb 1, 2011·Vascular and Endovascular Surgery·Anne-Mette Hedeager MomsenJes Sanddal Lindholt
Apr 18, 2013·Medicine and Science in Sports and Exercise·Hans K StadheimJørgen Jensen
Jul 1, 2014·Medicine and Science in Sports and Exercise·Rahchell S CornishTina L Skinner
Oct 24, 2015·Journal of Applied Physiology·Hans Kristian StadheimJørgen Jensen

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