PMID: 2111252Mar 1, 1990Paper

Randomized double-blind, placebo-controlled clinical trial of a selective 5-lipoxygenase inhibitor (AA-861) for the prevention of seasonal allergic rhinitis

The Journal of International Medical Research
R J AncillJ R Smith

Abstract

In a randomized, double-blind, parallel group trial conducted in eight European centres, the 5-lipoxygenase inhibitor AA-861 was administered orally, starting 2 weeks before the pollen season and continuing for 8 weeks; after the start of the season escape medication was permitted if necessary. Patients were enrolled who had a previous history of pollen allergy, confirmed by skin prick tests and/or relevant allergen-specific immunoglobulin E to pollen. Daily symptoms scores were recorded on diary cards and assessments were made by the investigator during the study period. Better global improvement ratings were achieved using AA-861, as assessed both by the investigators and the patients. The total nasal symptoms scores and activities of daily living were also improved compared to placebo. No significant adverse reactions were encountered.

References

Dec 1, 1983·Prostaglandins·Y AshidaY Maki

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Citations

Dec 12, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B J Lipworth
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·J Ghosh, C E Myers
Nov 4, 2009·The Journal of Bone and Joint Surgery. American Volume·Jessica A Cottrell, J Patrick O'Connor
Dec 15, 2012·Pharmacological Reports : PR·Grzegorz A CzapskiRobert P Strosznajder
Jan 27, 2007·The Cochrane Database of Systematic Reviews·M A CalderonS Durham
Dec 3, 1999·Toxicology and Applied Pharmacology·J K Huang, C R Jan
Aug 1, 1992·Trends in Pharmacological Sciences·R M McMillan, E R Walker
Feb 21, 2004·Biochemical and Biophysical Research Communications·Jagadananda Ghosh
Dec 16, 1998·Respiratory Medicine·S J Lane

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