Randomized double blinded controlled trial to evaluate the efficacy and safety of Bifilac in patients with acute viral diarrhea.

Indian Journal of Pediatrics
D Narayanappa

Abstract

To evaluate the efficacy and safety of Bifilac on reducing the episodes (frequency) and duration of diarrhea induced by rotaviral infection and to evaluate the efficacy of Bifilac to ameliorate the associated symptoms like dehydration and duration of rotaviral shedding in faeces. 80 children aged between 3 months and 3 years were enrolled and divided into 2 groups, one group received standard therapy + placebo, the other group received standard therapy + probiotic (Bifilac) randomly. Children assessed for frequency and duration of diarrhea. Degree of dehydration, duration and volume of oral rehydration salt [ORS] therapy, duration and volume of Intra venous fluids and duration of rotaviral shedding. When compared to the placebo, Bifilac showed clinical as well as statistically significant reduction in Number of episodes (frequency) of diarrhea in a day, mean duration of diarrhea (in days) degree of dehydration, duration and volume of oral rehydration salt [ORS] therapy, duration and volume of intravenous fluid [IVF] therapy, duration of rotaviral shedding (P<0.01). The synbiotic, bifilac, appears to be a safe and very effective adjuvant in the management of acute rotaviral diarrhea.

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Citations

Apr 22, 2009·Indian Journal of Pediatrics·Seema Alam
Jan 11, 2014·Expert Opinion on Drug Safety·Tina DidariMohammad Abdollahi
Nov 16, 2010·Gastroenterology·Geoffrey A PreidisJames Versalovic
Jun 26, 2010·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·T Iannitti, B Palmieri
Mar 27, 2015·Beneficial Microbes·M van den NieuwboerE Claassen
Oct 1, 2018·World Journal of Pediatrics : WJP·Jie ChenYong-Sui Dong
Nov 12, 2010·The Cochrane Database of Systematic Reviews·Stephen J AllenLeonila F Dans
Dec 10, 2020·The Cochrane Database of Systematic Reviews·Shelui CollinsonStephen J Allen
Apr 17, 2020·Current Pharmaceutical Biotechnology·Fereshteh AnsariHadi Pourjafar
Jun 13, 2020·Gastroenterology·Geoffrey A PreidisRebecca L Morgan
Aug 6, 2021·Current Microbiology·Zhiming LvZeliang Chen

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