Randomized multicentre feasibility trial of intermediate care versus standard ward care after emergency abdominal surgery (InCare trial)

The British Journal of Surgery
Morten Vester-AndersenInCare trial group

Abstract

Emergency abdominal surgery carries a considerable risk of death and postoperative complications. Early detection and timely management of complications may reduce mortality. The aim was to evaluate the effect and feasibility of intermediate care compared with standard ward care in patients who had emergency abdominal surgery. This was a randomized clinical trial carried out in seven Danish hospitals. Eligible for inclusion were patients with an Acute Physiology And Chronic Health Evaluation (APACHE) II score of at least 10 who were ready to be transferred to the surgical ward within 24 h of emergency abdominal surgery. Participants were randomized to either intermediate care or standard surgical ward care after surgery. The primary outcome was 30-day mortality. In total, 286 patients were included in the modified intention-to-treat analysis. The trial was terminated after the interim analysis owing to slow recruitment and a lower than expected mortality rate. Eleven (7·6 per cent) of 144 patients assigned to intermediate care and 12 (8·5 per cent) of 142 patients assigned to ward care died within 30 days of surgery (odds ratio 0·91, 95 per cent c.i. 0·38 to 2·16; P = 0·828). Thirty (20·8 per cent) of 144 patients assigned to i...Continue Reading

Associated Clinical Trials

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Citations

Jul 16, 2016·Acta Anaesthesiologica Scandinavica·M S HansenJ Wetterslev
Nov 2, 2016·The British Journal of Surgery·R B HasselagerM H Møller
Jan 24, 2017·The British Journal of Surgery·L T TengbergUNKNOWN AHA study group
Jul 19, 2017·World Journal of Surgery·Henrik WolstedMorten Vester-Andersen
Jan 19, 2019·Acta Anaesthesiologica Scandinavica·Sarah EkeloefIsmail Gögenur
Jan 25, 2019·Anesthesia and Analgesia·Nicholas MendisUNKNOWN Canadian Perioperative Anesthesia Clinical Trials Group (PACT)
Sep 19, 2019·Acta Anaesthesiologica Scandinavica·Anna K HanstedMorten Vester-Andersen
May 10, 2020·Acta Anaesthesiologica Scandinavica·Anna K HanstedUNKNOWN InCare trial Group
Apr 6, 2016·European Journal of Anaesthesiology·Kjetil SøreideBernhard Walder
Aug 15, 2021·British Journal of Anaesthesia·Anne A AaenBirgitte Brandstrup

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