PMID: 359083Sep 1, 1978Paper

Randomized multicentre trial of oral bowel preparation and antimicrobials for elective colorectal operations

The British Journal of Surgery
D M MathesonM R Keighley

Abstract

A study of 120 patients undergoing elective colorectal operations has investigated the effect of adding oral neomycin and metronidazole to bowel preparation in a double-blind randomized controlled trial. Comparisons have also been made between a standard mechanical preparation and the use of an elemental diet. The addition of neomycin and metronidazole to bowel preparation significantly reduced the rate of wound sepsis (P less than 0.01), septicaemia (P less than 0.02) and anastomotic dehiscence (P less than 0.02); anaerobic infections were abolished and there was a significant reduction in the incidence of aerobic Gram-negative infections. Elemental diets were shown to have no advantage over mechanical preparation.

References

Oct 1, 1977·The British Journal of Surgery·Y ArabiM R Keighley
Mar 18, 1978·British Medical Journal·A KappasM R Keighley
Jul 1, 1976·The British Journal of Surgery·M R KeighleyJ Alexander-Williams
May 1, 1977·The British Journal of Surgery·M R Keighley
May 14, 1977·British Medical Journal·H E LarsonD A Tyrrell
Apr 1, 1976·Scottish Medical Journal·M R Keighley, A R Crapp
Dec 1, 1976·The British Journal of Surgery·J F Gurry, R B Ellis-pegler
Jan 1, 1976·American Journal of Surgery·H H LeVeenM Patel
May 1, 1973·The British Journal of Surgery·R C Burton
Aug 1, 1972·Annals of Surgery·Ronald Lee NicholsL M Nyhus
Jun 1, 1973·The British Journal of Surgery·T T Irvin, J C Goligher
Jan 1, 1974·Archives of Surgery·W C Johnson
Aug 1, 1969·The British Journal of Surgery·R A SellwoodR B Welbourn
Sep 1, 1969·The British Journal of Surgery·M T EverettJ Nettleton

Citations

May 1, 1982·World Journal of Surgery·M R Keighley
Mar 1, 1982·World Journal of Surgery·I Cohn, G H Bornside
Mar 1, 1982·World Journal of Surgery·M M Hares, J Alexander-Williams
Mar 1, 1982·World Journal of Surgery·R E Condon
Mar 1, 1993·World Journal of Surgery·W T Morris
Jan 1, 1984·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·P BlomquistB Zederfeldt
Jan 13, 2001·Diseases of the Colon and Rectum·S Galandiuk, N Mortensen
Jan 1, 1981·Diseases of the Colon and Rectum·J C BonelloR R Manson
May 22, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Benjamin D ShoganKonstantin Umanskiy
May 1, 1987·Journal of Pediatric Surgery·J J VilaS Ruiz
Sep 13, 1980·British Medical Journal·N A Matheson, D Valerio
Feb 18, 2016·Surgical Infections·Donald E Fry
Jun 12, 2012·Current Problems in Surgery·Supriya S PatelAnthony J Senagore
Oct 1, 2011·Advances in Surgery·Danielle FritzeDarrell A Campbell
Mar 25, 2011·American Journal of Surgery·Donald E Fry
Dec 1, 1993·Baillière's Clinical Gastroenterology·P M Velez
Dec 4, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S A L AsariN K Kim
Aug 9, 2016·Current Problems in Surgery·Monika A KrezalekJohn C Alverdy
Jun 29, 2016·Langenbeck's Archives of Surgery·Donald E Fry
Aug 16, 2016·Advances in Surgery·Alice C A Murray, Ravi Pokala Kiran
Mar 13, 2018·Inflammatory Bowel Diseases·Igors IesalnieksChristina Hackl
May 13, 2014·The Cochrane Database of Systematic Reviews·Richard L NelsonMarija Barbateskovic
May 1, 1981·The British Journal of Surgery·J G Gray, M J Lee
Mar 1, 1981·The British Journal of Surgery·J A WalshJ J Finlay-Jones
Apr 28, 2005·Chemotherapy·Ronald Lee NicholsChristopher B Weldon
Sep 9, 2011·The Cochrane Database of Systematic Reviews·K F GuenagaP Wille-Jørgensen
Sep 1, 1984·Pharmacotherapy·T G Burnakis
Jan 1, 1981·Scandinavian Journal of Gastroenterology·D Raahave
Jun 4, 2005·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·P Wille-JørgensenA A Castro
Dec 12, 2018·Diseases of the Colon and Rectum·John MigalyClinical Practice Guidelines Committee of the American Society of Colon and Rectal Surgeons
May 1, 1987·Drug Intelligence & Clinical Pharmacy·L Danziger, E Hassan
Jun 16, 2019·Updates in Surgery·Alice Frontali, Yves Panis
Sep 29, 2020·International Journal of Colorectal Disease·Evgeny RybakovYuri Shelygin
May 12, 2006·World Journal of Gastroenterology : WJG·Mohammad U NasirkhanRobert Kozol
Jul 18, 2020·Annals of Coloproctology·Jin Soo Han, Seok-Byung Lim

Related Concepts

Clinical Trials
Taenia Coli
Double-Blind Method
Food, Formulated
Bayer 5360
Neomycin Palmitate
Preoperative Procedure
Randomization
Rectum
Surgical Wound Dehiscence

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