Randomized phase 3 evaluation of trifarotene 50 μg/g cream treatment of moderate facial and truncal acne

Journal of the American Academy of Dermatology
Jerry TanLinda Stein Gold

Abstract

Acne vulgaris often affects the face, shoulders, chest, and back, but treatment of nonfacial acne has not been rigorously studied. Assess the safety and efficacy of trifarotene 50 μg/g cream, a novel topical retinoid, in moderate facial and truncal acne. Two phase III double-blind, randomized, vehicle-controlled, 12-week studies of once-daily trifarotene cream versus vehicle in subjects aged 9 years or older. The primary end points were rate of success on the face, as determined by the Investigator's Global Assessment (clear or almost clear and ≥2-grade improvement), and absolute change from baseline in inflammatory and noninflammatory counts from baseline to week 12. The secondary end points were rate of success on the trunk (clear or almost clear and ≥2-grade improvement) and absolute change in truncal inflammatory and noninflammatory counts from baseline to week 12. Safety was assessed through adverse events, local tolerability, vital signs, and routine laboratory testing results. In both studies, at week 12 the facial success rates according to the Investigator's Global Assessment and truncal Physician's Global Assessment and change in inflammatory and noninflammatory lesion counts (both absolute and percentage) were all hi...Continue Reading

Citations

Nov 13, 2019·Drugs·Lesley J Scott
Jul 16, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·U Blume-PeytaviE Tanghetti
Feb 27, 2020·Journal of Cosmetic Dermatology·Martin KassirMohamad Goldust
Apr 8, 2020·JAMA : the Journal of the American Medical Association
May 19, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·Florence PoliBrigitte Dréno
Jun 23, 2020·The Annals of Pharmacotherapy·Katheryn A BellLaura Boger
Mar 20, 2019·American Journal of Clinical Dermatology·Kathy A Fraser
Jan 8, 2021·Dermatology and Therapy·Jane J HanArash Mostaghimi
Feb 14, 2021·Indian Journal of Dermatology, Venereology and Leprology·Anupam DasBhushan Madke
Mar 4, 2021·Biomedicines·Terenzio CosioElena Campione
Mar 31, 2021·Journal of Medicinal Chemistry·Andrew C FlickChristopher J O'Donnell
Apr 20, 2021·Dermatology and Therapy·Linda Stein Gold, Thomas Dirschka
Apr 20, 2021·American Journal of Clinical Dermatology·Hilary BaldwinEric Guenin
Apr 21, 2021·Dermatology and Therapy·Jerry K L Tan, Thomas Dirschka
May 14, 2021·Actas dermo-sifiliográficas·A Guerra-Tapia, E González-Guerra
Jul 11, 2021·Indian Journal of Dermatology, Venereology and Leprology·Parvathy Santhosh, Ajithkumar Kidangazhiathmana
Aug 5, 2021·Therapeutics and Clinical Risk Management·Caitlin M BrumfielMichael A Cardis
Aug 31, 2021·The Journal of Dermatological Treatment·Leon H KircikBinu Alexander
Nov 9, 2021·Frontiers in Medicine·Brigitte DrenoJayendra Kumar Krishnaswamy
Nov 24, 2021·JAMA : the Journal of the American Medical Association·Dawn Z EichenfieldLawrence F Eichenfield
Jan 19, 2022·American Journal of Clinical Dermatology·Lara DrakeArash Mostaghimi

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