Randomized placebo-controlled clinical trial of immunoglobulin Y as adjunct to standard supportive therapy for rotavirus-associated diarrhea among pediatric patients

Vaccine
Shofiqur RahmanKeiji Oguma

Abstract

This study aims to evaluate the effect of hyperimmune immunoglobulin Y (IgY) against human rotavirus (HRV) among pediatric patients receiving standard supportive treatment for rotavirus-associated diarrhea mostly with an enteric non-cholera co-pathogen in a hospital setting. Two natural HRV reassortant clinical strains ATCC VR 2273 and ATCC VR 2274 were used as mixed immunizing antigens in poultry hens to generate anti-HRV IgY (Rotamix IgY). The Rotamix IgY was used in laboratory and clinical studies against control or placebo IgY. The control or placebo IgY was prepared using tissue culture medium from mock-infected MA104 cell line as antigen for poultry immunization. In vitro, Rotamix IgY exhibited multi-serotypic cross neutralization activities along with synergistic effects against major global serotypes G1, G2, G3, G4 and other human or animal rotavirus strains when compared with mono-specific IgY. Suckling mice (ICR strain) pre-treated orally once with Rotamix IgY and then challenged with rotavirus 3h later showed a significant dose-dependent reduction in frequency (p<0.05) and duration (p<0.05) of diarrhea compared to placebo IgY-treated mice. Out of 114 children aged between 3 and 14 months and with diarrhea upon admiss...Continue Reading

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Citations

Dec 1, 2012·Current Opinion in Gastroenterology·Eugenia BruzzeseAlfredo Guarino
Jan 21, 2015·Critical Reviews in Biotechnology·Russell G A Jones, Angela Martino
Sep 16, 2015·Japanese Journal of Infectious Diseases·Tomihiko IdeKoki Taniguchi
Aug 26, 2015·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·K ThomsenN Høiby
Jan 16, 2013·Human Vaccines & Immunotherapeutics·Shofiqur RahmanYoshikatsu Kodama
Mar 25, 2014·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Devona Williams
Jul 26, 2018·Journal of Immunoassay & Immunochemistry·Natália Maria LanzariniMarcelo Alves Pinto
Sep 20, 2018·Human Vaccines & Immunotherapeutics·Aymn Talat AbbasEsam Ibraheem Ahmed Azhar
Jun 17, 2020·Experimental and Therapeutic Medicine·Carolina ConstantinDemetrios A Spandidos
Jun 23, 2020·Journal of Immunology Research·Fatemeh NorouziSeyed Latif Mousavi Gargari
Jan 29, 2021·Journal of Immunology Research·Ruizhao CaiShaohai Qi
Jun 29, 2021·Frontiers in Immunology·Lucia LeeDaria Mochly-Rosen
Aug 21, 2021·International Journal of Biological Macromolecules·Mayara Torquato Lima da SilvaLivia Melo Villar

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