PMID: 8450247Apr 1, 1993Paper

Randomized placebo-controlled double-blind combined therapy with laser surgery and systemic interferon-alpha 2a in the treatment of anogenital condylomata acuminatum. The Condylomata International Collaborative Study Group

The Journal of Infectious Diseases

Abstract

An earlier study by this group failed to demonstrate significant therapeutic effect of 4 weeks of systemic recombinant interferon (IFN)-alpha 2 monotherapy on anogenital condylomata acuminatum. The present study was undertaken to determine if 3 MIU of IFN given three times weekly for 4 consecutive weeks and starting immediately after CO2 laser ablation of all visible warts would be effective. In a multicenter placebo-controlled randomized double-blinded study of 130 evaluatable patients followed for 36 weeks after treatment, no beneficial effects were noted in terms of complete response (24 placebo vs. 23 IFN patients) and recurrences (38 placebo vs. 46 IFN patients). None of the pretreatment and demographic characteristics affected outcome with statistically significant differences. CO2 laser ablation combined with systemic recombinant IFN-alpha 2 was ineffective in this study as treatment of anogenital condylomata.

Citations

Oct 1, 1995·Diseases of the Colon and Rectum·S M Congilosi, R D Madoff
Feb 1, 1995·Pharmacology & Therapeutics·P F Rockley, S K Tyring
Jul 1, 1994·Antiviral Research·R Cirelli, S K Tyring
May 1, 1997·Clinics in Dermatology·G Gross, G Von Krogh
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Sep 21, 2001·Best Practice & Research. Clinical Obstetrics & Gynaecology·C Sonnex, C J Lacey
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Aug 19, 2017·Sexually Transmitted Infections·Lukas WestfechtelAlexander Nast
Apr 16, 1998·Genitourinary Medicine·G StellatoJ Paavonen
Oct 1, 1994·British Journal of Obstetrics and Gynaecology·D Luesley
Jun 13, 2006·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Ashraf BadawiManal Salah
Jan 15, 1999·International Journal of Dermatology·D S Hurd, E T Conte
Sep 28, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D J WileyLynne Fukumoto

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