Randomized placebo-controlled trial of CDB-2914 in new users of a levonorgestrel-releasing intrauterine system shows only short-lived amelioration of unscheduled bleeding

Human Reproduction
P WarnerH O D Critchley


The levonorgestrel-releasing intrauterine system (LNG-IUS) is a highly effective contraceptive. However, during early months of use unscheduled vaginal bleeding is common, sometimes leading to discontinuation. This study aimed to determine whether intermittent administration of progesterone receptor modulator CDB-2914 would suppress unscheduled bleeding during the first 4 months after insertion of the LNG-IUS. CDB-2914 150 mg, in divided doses, or placebo tablets, were administered over three consecutive days starting on Days 21, 49 and 77 after LNG-IUS insertion, in a double-blind randomized controlled trial of women aged 19-49 years, newly starting use of LNG-IUS. Daily bleeding diaries were completed for 6 months, and summarized across blocks as percentage days bleeding/spotting (BS%). Of 69 women randomized to receive CDB-2914, and 67 placebo, 61 and 55, respectively, completed the trial. BS% decreased with time in both arms, but showed a much steeper treatment-phase gradient in the placebo arm (P < 0.0001), so that a benefit of CDB-2914 in the 28 days after first treatment (-11% points, 95% CI -19 to -2), converted to a disadvantage by 64 days after the third treatment (+10% points, 95% CI 1-18). The effect of CDB-2914 on ...Continue Reading


Jul 1, 1990·Contraception·I BarbosaE D Johansson
Mar 1, 1996·American Journal of Obstetrics and Gynecology·F Alvarez-SanchezA Faundes
Mar 31, 2000·BJOG : an International Journal of Obstetrics and Gynaecology·T BackmanM Koskenvuo
Jun 23, 2004·Contraception·María Rebeca MassaiCatherine d'Arcangues
Nov 18, 2005·The New England Journal of Medicine·Herbert B Peterson, Kathryn M Curtis
Jan 27, 2006·The Cochrane Database of Systematic Reviews·V HalpernM F Gallo
Apr 20, 2007·The Cochrane Database of Systematic Reviews·H Abdel-AleemA M Gülmezoglu
May 29, 2007·Contraception·Anja Guttinger, Hilary O D Critchley

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