PMID: 9189106Jun 1, 1997Paper

Randomized placebo-controlled trial of teicoplanin in the antibiotic prophylaxis of infection following manipulation of burn wounds

The British Journal of Surgery
J A SteerN Parkhouse

Abstract

Burn wound surgery or change of dressings commonly causes bacteraemia. The use of antibiotic prophylaxis has not been tested adequately in a controlled trial. A randomized double-blind placebo-controlled study was performed to determine the effect on Gram-positive bacteraemia and clinical outcome of a single dose of teicoplanin (12 mg/kg intravenously) given at burns surgery or change of dressings. A total of 134 patients were entered into the study, representing 220 episodes of dressing or debridement (110 episodes in each group). There was a significant difference between the groups with respect to perioperative Gram-positive bacteraemia: eight episodes (7 per cent) in the teicoplanin group versus 51 (46 per cent) in the placebo group (P < 0.001). However, good clinical outcome was similar in both groups (80 of 110 versus 77 of 110 respectively, P = 0.7). Only eleven patients had bacteraemia caused by Gram-negative species alone. Bacteriological response in terms of wound culture showed no significant difference between the groups: 63 (57 per cent) of 110 episodes versus 58 (53 per cent) of 110 respectively respectively. Prevention of Gram-positive bacteraemia did not affect postoperative recovery.

References

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Citations

Jun 1, 1999·The Journal of Antimicrobial Chemotherapy·I F ChernA P Wilson
Mar 20, 2008·The Journal of Trauma·Laurie C D'AvignonLeopoldo C Cancio
Feb 17, 2010·BMJ : British Medical Journal·Tomer AvniMical Paul
Mar 15, 2016·The Journal of Dermatology·Yuichiro YoshinoUNKNOWN Wound/Burn Guidelines Committee
Oct 14, 2008·Journal of Burn Care & Research : Official Publication of the American Burn Association·Guillermo RamosFortunato Benaim

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