Randomized, single-blind, trial of sertraline and buspirone for treatment of elderly patients with generalized anxiety disorder

Psychiatry and Clinical Neurosciences
Naghmeh MokhberMalcolm Hopwood

Abstract

Generalized anxiety disorder (GAD) in elderly people is common, but few systematic studies regarding the best treatments have been performed. The aim of the present study was to evaluate the efficacy and safety of sertraline and buspirone in the treatment of elderly patients with GAD. Based on selection criteria, 46 patients were recruited who met DSM-IV criteria for GAD. Patients were randomly assigned to sertraline (50-100 mg/day) or buspirone (10-15 mg/day) for 8 weeks in a single-blind trial. The primary outcome measure used in the present study was the Hamilton Rating Scale for Anxiety (HRSA). Both sertraline and buspirone had significant anxiolytic efficacy. A steady decrease in the total HRSA scores for both groups was observed throughout the study period. After 2 and 4 weeks, buspirone was found to be significantly superior to sertraline (P < 0.001), but at the end of study period this difference did not reach statistical significance (P = 0.16). The mean HRSA score after 8 weeks significantly decreased in subjects treated with sertraline (P < 0.001), and buspirone (P < 0.001). No clinically adverse events or changes in laboratory test results were observed during the study period. Both sertraline and buspirone appear t...Continue Reading

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Citations

Sep 29, 2011·Expert Opinion on Pharmacotherapy·Jennifer A ReinholdFalk W Lohoff
Sep 13, 2011·Journal of Anxiety Disorders·Daniela C Gonçalves, Gerard J Byrne
May 20, 2015·Current Psychiatry Reports·Carmen Andreescu, Daniel Varon
Jun 5, 2016·Primary Care·Joseph J BenichJohn R Freedy
Sep 4, 2016·Neuroscience and Biobehavioral Reviews·Carol A ShivelyStephanie L Willard
Sep 28, 2017·Current Treatment Options in Psychiatry·Elizabeth A CroccoKatherine Camfield
Dec 7, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Charlotte BroersAns Pauwels

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