PMID: 9637897Jun 25, 1998Paper

Randomized, single-blinded comparative study of the efficacy of amoxicillin (40 mg/kg/day) versus standard-dose penicillin V in the treatment of group A streptococcal pharyngitis in children

Clinical Pediatrics
I GopichandJ Goldfarb

Abstract

A 10-day course of amoxicillin at a dosage of 40 mg per kilogram per day was compared with conventional (lower dosage) penicillin V therapy in the treatment of culture-proven Group A streptococcal pharyngitis in children 3 to 18 years of age in a prospective, randomized, and single-blinded study. Children had to have signs and symptoms compatible with the diagnosis of streptococcal pharyngitis and to have a throat swab positive for Group A streptococci. A second throat culture was obtained 10 to 14 days after the completion of therapy. Serotyping was performed to help differentiate carrier states from reinfections. Of 161 children enrolled, 113 were evaluable; 55 received penicillin and 58 received amoxicillin. At the completion of therapy 70.9% (39/55) of patients in the penicillin group vs 87.9% (51/58) of patients in the amoxicillin group were asymptomatic (clinical cure, P = 0.025). At the completion of therapy, 54.5% (30/55) of patients in the penicillin group vs 79.3% (46/58) of patients in the amoxicillin group had negative throat cultures (bacteriologic cure, P = 0.005). The carrier rate (children who were well but who were still carrying the same serotype of Group A streptococcus) also differed between the groups: 13 (...Continue Reading

References

Jan 1, 1977·Southern Medical Journal·T Q Spitzer, B A Harris
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Citations

Aug 31, 2006·The Pediatric Infectious Disease Journal·Herbert W CleggP Michael Giftos
Jun 15, 2007·Infectious Disease Clinics of North America·Maria L Alcaide, Alan L Bisno
Mar 5, 2004·The Journal of International Medical Research·U B Schaad
Aug 9, 2006·Clinical Pediatrics·Michael E Pichichero
Feb 25, 2005·Advances in Therapy·Alexander K C Leung, James D Kellner
Aug 14, 2020·European Journal of Clinical Investigation·Reuben K MutagaywaSteven Chamuleau

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