Randomized study comparing vitamin D3 and 1α-Hydroxyvitamin D3 in combination with pegylated interferon/ribavirin therapy for chronic hepatitis C

Journal of Gastroenterology and Hepatology
Yoshie Omori-MizunoSatoshi Mochida

Abstract

An intention-to-treat prospective randomized study was carried out to compare the potentiation of antiviral efficacies between cholecalciferol, non-activated vitamin D3 supplement, and alfacalcidol, activated 1α-Hydroxyvitamin D3 [1α (OH)-vitamin D3]. Chronic hepatitis patients with genotype 1b hepatitis C virus (HCV) infection showing serum HCV-RNA levels greater than 5 Log IU/mL received oral administration of cholecalciferol (2000 IU/day) or alfacalcidol (0.5 μg/day) for 4 weeks, and then they were given pegylated interferon (Peg-IFN)-α2a plus ribavirin therapy in combination with either vitamin D3 for 48 or 72 weeks according to the response-guided manner. A total of 36 patients were evaluated. Serum 25-hydroxyvitamin D3 [25(OH)-D3] levels were increased only in patients in the cholecalciferol group during the lead-in vitamin D administration, and the levels at 4 weeks were higher in these patients than in those in the alfacalcidol group (P < 0.001), while serum 1α,25-dihydroxyvitamin D3 [1α,25(OH)2 -D3] levels were not different between both groups. Rapid virological response was obtained in six (33%) patients in the cholecalciferol group; the ratio was higher than that in the alfacalcidol group (one patient; 6%, P < 0.05)...Continue Reading

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Citations

Aug 5, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tomomi OkuboKatsuhiko Iwakiri
Mar 23, 2017·BMJ Open Gastroenterology·Noemi Hernández-AlvarezManuel Hernández-Guerra
Apr 18, 2018·European Journal of Gastroenterology & Hepatology·Chao-Nan JinJi-Fang Sheng
Nov 27, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Takuya MatsumuraTakanobu Kato
Aug 26, 2021·The Cochrane Database of Systematic Reviews·Milica BjelakovicChristian Gluud

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