Randomized study of Lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Kimberly L BlackwellJoyce O'Shaughnessy

Abstract

Preclinical studies in ErbB2-positive cell lines demonstrated a synergistic interaction between lapatinib and trastuzumab, suggesting that dual blockade is more effective than a single agent alone. EGF104900 compared the activity of lapatinib alone or in combination with trastuzumab in patients with ErbB2-positive, trastuzumab-refractory metastatic breast cancer (MBC). Patients with ErbB2-positive MBC who experienced progression on prior trastuzumab-containing regimens were randomly assigned to receive either lapatinib alone or in combination with trastuzumab. The primary end point was progression-free survival (PFS). Secondary efficacy end points included overall response rate (ORR), clinical benefit rate (CBR; complete response, partial response, and stable disease for >/= 24 weeks), and overall survival (OS). In the intent-to-treat population (N = 296) who received a median of three prior trastuzumab-containing regimens, the combination of lapatinib with trastuzumab was superior to lapatinib alone for PFS (hazard ratio [HR] = 0.73; 95% CI, 0.57 to 0.93; P = .008) and CBR (24.7% in the combination arm v 12.4% in the monotherapy arm; P = .01). A trend for improved OS in the combination arm was observed (HR = 0.75; 95% CI, 0.53...Continue Reading

References

Aug 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M F PressK J Flom
Nov 3, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F RévillionJ P Peyrat
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles L VogelMichael Press
Mar 17, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Debu TripathyStanford J Stewart
Aug 16, 2006·Expert Opinion on Drug Safety·Karen Lisa SmithAndrew D Seidman
Nov 14, 2006·Breast Cancer Research : BCR·Rita Nahta, Francisco J Esteva
Nov 18, 2006·The Oncologist·Beverly Moy, Paul E Goss
Apr 4, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Rupert BartschGuenther G Steger
Jul 6, 2007·The New England Journal of Medicine·Clifford A Hudis
Aug 24, 2007·Expert Opinion on Pharmacotherapy·A MukherjeeStephen Chan
Jan 22, 2008·Breast Cancer Research and Treatment·John P CrownSteve Chan
Jan 24, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephen JohnstonNeil L Spector
Feb 20, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H J BursteinK L Blackwell
May 7, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Henry L GomezGeorge W Sledge
May 21, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anna Maria StornioloHoward A Burris
Oct 29, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Angelo Di LeoMichael F Press
Jan 31, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K L BlackwellH J Burstein
Mar 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gunter von MinckwitzSibylle Loibl

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Citations

Nov 13, 2010·European Journal of Nuclear Medicine and Molecular Imaging·David GroheuxElif Hindié
Jul 17, 2012·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Kohei ShitaraKei Muro
Nov 29, 2012·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Kensuke ShiraishiKoji Kono
Apr 9, 2013·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Narikazu Boku
Jul 16, 2010·International Journal of Clinical Oncology·Hirofumi Mukai
Oct 1, 2011·Breast Cancer Research and Treatment·Eugene R Ahn, Charles L Vogel
Dec 27, 2011·Breast Cancer Research and Treatment·Hope S RugoMaura N Dickler
Mar 13, 2013·Breast Cancer Research and Treatment·Alvaro Moreno-AspitiaEdith A Perez
Jun 14, 2012·Clinical & Experimental Metastasis·Alison T StopeckHope S Rugo
Aug 7, 2012·Journal of Mammary Gland Biology and Neoplasia·Justin Cidado, Ben Ho Park
Dec 1, 2011·Targeted Oncology·Nicholas A BarberMojtaba Akhtari
Feb 5, 2013·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Ricardo H Alvarez, Gabriel N Hortobagyi
Dec 15, 2012·CNS Drugs·Rupert BartschMatthias Preusser
Nov 13, 2013·The Breast : Official Journal of the European Society of Mastology·Elvin Blanco, Mauro Ferrari
Apr 6, 2013·Cancer Treatment Reviews·Lesley-Ann MartinGuy Jerusalem
Apr 9, 2011·Nature Medicine·Senthil K Muthuswamy
Jun 15, 2012·Nature Reviews. Cancer·Robert J GilliesRobert A Gatenby
Jul 13, 2012·Nature Reviews. Cancer·Yosef Yarden, Gur Pines
Nov 30, 2011·Nature Reviews. Clinical Oncology·Carlos L ArteagaLuca Gianni
Jan 30, 2013·Nature Reviews. Clinical Oncology·Sook Ryun ParkShivaani Kummar
Mar 14, 2012·Nature Reviews. Clinical Oncology·Lisa A Carey
Sep 4, 2013·Nature Reviews. Clinical Oncology·Elizabeth A KuczynskiRobert S Kerbel
Oct 30, 2010·Nature Reviews. Drug Discovery·Shivanni KummarJames H Doroshow
Apr 24, 2010·Nature Reviews. Immunology·Louis M WeinerShangzi Wang
Nov 30, 2012·The New England Journal of Medicine·Gregory M CoteBruce A Chabner
Oct 14, 2011·The New England Journal of Medicine·Daniel F Hayes
Dec 14, 2011·The New England Journal of Medicine·William J Gradishar
Aug 25, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A Santoro, G Gullo
Oct 15, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J Baselga
Aug 21, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G MetroS Gori
Mar 17, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Y WuH J Burstein
May 3, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E M OlsonH J Burstein
Jun 15, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D LenihanJ Baselga
Oct 20, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F CardosoUNKNOWN ESMO Guidelines Working Group
Nov 1, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S GoriD Crivellari
Aug 7, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M S N Mohd SharialB T Hennessy
Nov 20, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F CardosoUNKNOWN ESMO Guidelines Working Group
Sep 13, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A AwadaE Staroslawska
Sep 26, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B Sousa, F Cardoso
Jul 24, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J CrownV Diéras
Oct 26, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G S FalchookR Kurzrock
Jun 15, 2010·Japanese Journal of Clinical Oncology·Charles VogelHanlim Moon

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