Randomized study of single instillation of epirubicin for superficial bladder carcinoma: long-term clinical outcomes

Cancer Investigation
Benchun LiuYuanfang Zhang

Abstract

Intravesical instillation of epirubicin (EPI) is one of the most effective adjuvant therapies for nonmuscle-invasive bladder cancer postoperation. We evaluated the long-term efficacy of single dose intravesical epirubicin for superficial bladder carcinoma recurrence. Between June 1997 and May 1998, a total of 47 patients with resectable superficial bladder carcinoma (Ta-1, Grade 1-2), primary or recurrent with no recurrence during last one year, were enrolled in this study. All patients were randomized into 3 study groups: Group A-single epirubicin (80 mg/40 mL of normal saline) was administered into the bladder within 6 hours postoperation; Group B-40 mg Epirubicin consecutively; Group C-40 mg mitomycin C, consecutively. In Group B and C, instillation were given every week for 6- 8 weeks and then every one month for 10 months. Patients were followed up at 3, 6, 9, 12, 18, 24, 36, 48, and 60 months of treatment. The analyzed background factors were the therapeutic method, tumor recurrence, and side effects. Of the 47 patients, 43 (91.5 percent) were eligible and were followed up for 5 years postoperation. The disease free intervals of the three groups were found to have no significant differences (F = 10.28, p > 0.05). The recu...Continue Reading

References

May 5, 1999·International Journal of Urology : Official Journal of the Japanese Urological Association·T KondoH Toma
Jan 22, 2003·International Journal of Urology : Official Journal of the Japanese Urological Association·Isao HaraUNKNOWN Kobe Urogenital Tumor Study Group

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Citations

Mar 29, 2008·Pharmaceutical Research·Zancong ShenJessie L-S Au
Jan 19, 2010·Expert Opinion on Investigational Drugs·Marc C SmaldoneJeffrey R Gingrich
Apr 9, 2008·Current Opinion in Oncology·Daniel A Barocas, Peter E Clark
Nov 30, 2010·World Journal of Urology·Alon Z WeizerJeffrey S Montgomery

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