Randomized study of testosterone gel as adjunctive therapy to sildenafil in hypogonadal men with erectile dysfunction who do not respond to sildenafil alone

The Journal of Urology
R ShabsighH Padma-Nathan

Abstract

We compare the efficacy of testosterone gel (T-gel) versus placebo as adjunctive therapy to sildenafil in hypogonadal men with erectile dysfunction who do not respond to sildenafil alone. A randomized, placebo controlled, double-blind, parallel group, multicenter study was performed. A total of 75 hypogonadal men (18 to 80 years old, morning serum total testosterone 400 ng/dl or less) with confirmed lack of response to sildenafil monotherapy were randomized (1:1) to receive a daily dose of 1% T-gel or 5 gm placebo gel as adjunctive therapy to 100 mg sildenafil during a 12-week period. Subjects were evaluated for sexual function, primarily based on the International Index of Erectile Function (IIEF), quality of life and serum testosterone levels at baseline and weeks 4, 8 and 12. Testosterone treated subjects had greater improvement in erectile function compared to those who received placebo, reaching statistical significance at week 4 (4.4 vs 2.1, p = 0.029, 95.1% CI 0.3, 4.7). Similar trends were observed for improvements in orgasmic function, overall satisfaction, total IIEF score and percentage of IIEF responders. T-gel significantly (p < or =0.004) increased total and free testosterone levels throughout the study, although ...Continue Reading

References

Jul 7, 1993·JAMA : the Journal of the American Medical Association
Oct 7, 1997·International Journal of Impotence Research·A R Fugl-MeyerK S Fugl-Meyer
Jul 12, 2002·The Urologic Clinics of North America·Mark A Moyad
Jul 5, 2003·Current Medical Research and Opinion·Andrea SaloniaFrancesco Montorsi

❮ Previous
Next ❯

Citations

Nov 4, 2006·World Journal of Urology·Jacques Buvat, Gilbert Bou Jaoudé
Apr 22, 2005·Reviews in Endocrine & Metabolic Disorders·S H TariqJ E Morley
Apr 22, 2005·Reviews in Endocrine & Metabolic Disorders·Alvaro Morales
Oct 21, 2006·Current Urology Reports·Raymond C RosenJohn B Kostis
Jun 8, 2011·Current Urology Reports·Alvaro Morales
Jun 1, 2005·European Urology·M E BeutelUNKNOWN Hypogonadism Investigator Group
Jul 22, 1999·Urology·W D Steers
Jun 24, 2011·International Journal of Impotence Research·D J MoskovicM Khera
Apr 18, 2013·Nature Reviews. Endocrinology·Matthew SpitzerShalender Bhasin
Jan 15, 2005·International Journal of Impotence Research·G CoronaM Maggi
Sep 2, 2005·International Journal of Impotence Research·G CoronaM Maggi
Jan 6, 2006·International Journal of Impotence Research·T I-S HwangY C Lin
Aug 19, 2007·International Journal of Impotence Research·A A MakhloufC Neiderberger
Feb 29, 2008·International Journal of Impotence Research·T I S Hwang, Y-C Lin
Mar 17, 2011·Journal of Sex Research·Eric Johan H Meuleman
Feb 1, 2007·AIDS Patient Care and STDs·Nancy F Crum-CianfloneMark R Wallace
Jun 11, 2005·The Journal of Urology·Christian W KratzikJohannes Huber
Jun 11, 2005·The Journal of Urology·Drogo K MontagueUNKNOWN Erectile Dysfunction Guideline Update Panel
Jan 26, 2011·JAAPA : Official Journal of the American Academy of Physician Assistants·Bettie CoplanJames Roch
Jun 20, 2006·International Journal of Clinical Practice·P J Wright
Aug 31, 2006·International Journal of Clinical Practice·G Hackett
Aug 31, 2006·International Journal of Clinical Practice·R ShabsighJ Buvat
Mar 9, 2007·International Journal of Clinical Practice·M M Miner, A D Seftel
Jul 25, 2009·International Journal of Clinical Practice·G Hackett
Dec 17, 2011·International Journal of Clinical Practice·G Hackett
Jul 22, 2009·Journal of Strength and Conditioning Research·Jay R HoffmanAlan D Rogol
Apr 4, 2013·The Journal of Endocrinology·Daniel M Kelly, T Hugh Jones
Aug 27, 2009·Therapeutics and Clinical Risk Management·Nazem BassilJohn E Morley
Dec 22, 2006·Drugs·Sivaprakasam SivalingamHartwig Schwaibold
Oct 22, 2009·Pharmacogenomics·Ibrahim A Abdel-Hamid, Karl-Erik Andersson
Oct 25, 2012·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Naif AlhathalSerge Carrier
Mar 23, 2011·Asian Journal of Andrology·Rohit R DhirRun Wang
Apr 20, 2014·International Journal of Endocrinology·Pietro GareriPasquale De Fazio
Feb 16, 2010·Asian Journal of Andrology·Louis J Gooren
Apr 1, 2005·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·R Shabsigh
Dec 19, 2007·Asian Journal of Andrology·Nilgun GurbuzMustafa Faruk Usta
Nov 11, 2008·Journal of Endocrinological Investigation·G CoronaM Maggi
Dec 14, 2007·Journal of Endocrinological Investigation·A MorelliM Maggi
Apr 17, 2015·Current Sexual Health Reports·Alexander W Pastuszak
Oct 11, 2014·Pharmacogenomics·Riccardo Lacchini, Jose E Tanus-Santos

❮ Previous
Next ❯

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