Randomized study of the Arbeitsgemeinschaft Gynaekologische Onkologie Ovarian Cancer Study Group comparing quality of life in patients with ovarian cancer treated with cisplatin/paclitaxel versus carboplatin/paclitaxel

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Elfriede R GreimelArbeitsgemeinschaft Gynaekologische Onkologie Ovarian Cancer Study Group

Abstract

The objective of this study was to compare the quality of life (QoL) of ovarian cancer patients treated with paclitaxel/carboplatin (TC) versus paclitaxel/cisplatin (PT) and to determine the impact of treatment toxicity on the various QoL domains. In this phase III trial, 798 patients with ovarian cancer stages IIB-IV were randomly assigned to receive TC or PT. The primary end point was progression-free survival; secondary end points included toxicity, QoL, and response to treatment. Patients completed the European Organisation for Research and Treatment of Cancer QLQ-C30 before treatment, within 3 days before the second and the fourth chemotherapy cycle, and 3 weeks after completion of chemotherapy. Previously reported data showed that patients undergoing TC or PT did not differ in progression-free survival and overall survival. However, the TC arm was superior, indicating a better overall QoL compared with the PT arm. Controlling for toxicity and age, a significant treatment by assessment time interaction was found for four QoL functioning scales and three symptoms scales. Patients in the TC arm showed better means scores after treatment on overall QoL (P = .012), physical functioning (P = .012), role functioning (P = .005), ...Continue Reading

References

May 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K SwenertonG MacLean
Oct 1, 1991·Current Opinion in Oncology·W W ten Bokkel Huinink
Nov 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A H CalvertE Wiltshaw
Jul 2, 1997·JAMA : the Journal of the American Medical Association·A Leplège, S Hunt
Apr 1, 1997·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A du BoisH G Meerpohl
Jan 24, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D OsobaJ Pater
Dec 16, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M J HjermstadS Kaasa
Apr 3, 1999·British Journal of Cancer·P StoneR A'Hern
Oct 8, 1999·Journal of the National Cancer Institute·J E Groopman, L M Itri
Jan 7, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F M MuggiaJ M Small
Apr 12, 2000·International Journal of Radiation Oncology, Biology, Physics·A TrottiW Curran
May 24, 2001·Gynecologic Oncology·C M LakustaM G Campo
Jul 4, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R Schwarz, A Hinz
Oct 17, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D M ParkinS S Devesa
Feb 23, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P FayersUNKNOWN Quality of Life Unit
Jun 29, 2002·Clinical Journal of Oncology Nursing·Theresa W Gillespie
Mar 11, 2003·Cancer·Bernhard HolznerBarbara Sperner-Unterweger
Jul 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert F OzolsUNKNOWN Gynecologic Oncology Group
Sep 4, 2003·Journal of the National Cancer Institute·Andreas du BoisUNKNOWN Arbeitsgemeinschaft Gynäkologische Onkologie Ovarian Cancer Study Group
Oct 7, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrea BezjakElizabeth Eisenhauer
Apr 21, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·R F Ozols
Apr 21, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A Du Bois, J Pfisterer
Aug 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lari WenzelDavid Cella

❮ Previous
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Citations

Sep 18, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Dominique KoensgenUNKNOWN Nord-Ostdeutschen Gesellschaft für Gynäkologische Onkologie (NOGGO) working group "Quality of life"
Feb 22, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Anna BoltongSanchia Aranda
Jan 4, 2008·Current Treatment Options in Oncology·Thomas LoweLucille Leong
Feb 18, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·José A García-SáenzEduardo Díaz-Rubio
Aug 24, 2012·The Oncologist·Min Y TeoStuart M Lichtman
Jul 10, 2014·Journal of the National Cancer Institute·Kristine A DonovanLari Wenzel
Aug 10, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Elfriede R GreimelUNKNOWN Groupe d'Investigateurs Nationaux pour les Etudes des Cancers de l'Ovaire (GINECO)
Oct 3, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A du BoisUNKNOWN Norddeutsche Gesellschaft Fuer Gynaekologische Onkologie [NOGGO]
Jan 17, 2012·Hematology/oncology Clinics of North America·Jeanne CarterLari Wenzel
Nov 19, 2011·Gynecologic Oncology·Denise D Correa, Lisa M Hess
May 27, 2011·Cancer Treatment Reviews·Anna Boltong, Russell Keast
Mar 23, 2011·Obstetrics and Gynecology Clinics of North America·Amnon AmitLior Lowenstein
Dec 26, 2006·Critical Reviews in Oncology/hematology·Patrick PetignatDiane M Provencher
May 13, 2008·European Journal of Pain : EJP·Takao HidakaShigeru Saito
Sep 9, 2010·International Journal of Cancer. Journal International Du Cancer·Elfriede GreimelEdgar Petru
Sep 3, 2013·Gynecologic Oncology·Elfriede GreimelUNKNOWN European Organization for Research and Treatment of Cancer - Gynaecological Cancer Group and NCIC Clinical Trials Group
Mar 1, 2012·Gynecologic Oncology·Anne M van AltenaLambertus A Kiemeney
Aug 2, 2016·Expert Opinion on Drug Delivery·Fanfei MengYoon Yeo
Jan 15, 2017·Gynecologic Oncology·Jessica GillenKathleen Moore
Dec 24, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Tom HoyerJanneke P C Grutters
Nov 5, 2014·Therapeutic Advances in Medical Oncology·Seiya Sato, Hiroaki Itamochi
Aug 9, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Lisa M Hess, Frederick B Stehman
Aug 13, 2011·Expert Review of Pharmacoeconomics & Outcomes Research·Dana M Chase, Lari Wenzel
Feb 18, 2010·Expert Review of Pharmacoeconomics & Outcomes Research·Elfriede Greimel, Andrew John Nordin
Jul 20, 2018·Journal of Gynecologic Oncology·Michelle K WilsonMichael Friedlander
Jul 6, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Satyam KumarCarole Cummins
Mar 9, 2011·Bulletin du cancer·Coralie MoncharmontNicolas Magné
Nov 17, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J-M FerreroE Pujade-Lauraine
Feb 6, 2021·Journal of the National Comprehensive Cancer Network : JNCCN·Deborah K ArmstrongAnita M Engh
Apr 16, 2021·Journal of the National Comprehensive Cancer Network : JNCCN·Kah Poh LohMelisa L Wong
Oct 19, 2017·Gynecologic Oncology·Lauren E DockeryKathleen N Moore

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