Randomized Study on Dose Escalation in Definitive Chemoradiation for Patients With Locally Advanced Esophageal Cancer (ARTDECO Study).

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
M C C M HulshofAte van der Gaast

Abstract

To analyze the effect of radiation dose escalation to the primary tumor on local tumor control in definitive chemoradiation (dCRT) for patients with esophageal cancer. Patients with medically inoperable and/or irresectable esophageal carcinoma, referred for dCRT, were randomly assigned between a standard dose (SD) of 50.4 Gy/1.8 Gy for 5.5 weeks to the tumor and regional lymph nodes and a high dose (HD) up to a total dose of 61.6 Gy to the primary tumor. Chemotherapy consisted of courses of concurrent carboplatin (area under the curve 2) and paclitaxel (50 mg/m2) in both arms once a week for 6 weeks. The primary end point was local progression-free survival. Between September 2012 and June 2018, 260 patients were included. Squamous cell carcinoma (SCC) was present in 61% of patients, and 39% had adenocarcinoma (AC). Radiation treatment was completed by 94%, and 85% had at least five courses of chemotherapy. The median follow-up time for all patients was 50 months. The 3-year local progression-free survival (LPFS) was 70% in the SD arm versus 73% in the HD arm (not significant). The LPFS for SCC and AC was 75% versus 79% and 61% versus 61% for SD and HD, respectively (not significant). The 3-year locoregional progression-free su...Continue Reading

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Citations

Sep 24, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yun-Hsuan LinYu-Ming Wang
Sep 24, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maarten C C M HulshofUNKNOWN ARTDECO study group
Sep 24, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christoph PöttgenMartin Stuschke
Oct 26, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ronald ChowSangjune Laurence Lee

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