Randomized Study on Early Detection of Lung Cancer with MSCT in Germany: Results of the First 3 Years of Follow-up After Randomization

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
N BeckerS Delorme

Abstract

The German Lung Cancer Screening Intervention Trial (LUSI) is one of the European randomized trials investigating the efficacy of low-dose multislice computed tomography (MSCT) as a screening tool for lung cancer. In the evaluation of the first (prevalence) screening round, we observed exceptionally high early recall rates, which made the routine application of MSCT screening questionable. Because screening may behave differently in subsequent (incidence) screening rounds, we analyzed (a) basic characteristics for the annual rounds 2 to 4, which have now also been completed, and (b) the first 3 years with complete follow-up since time of randomization. Data material was the data record of LUSI after the fourth screening round and the 3-year follow-up had been completed. Basic characteristics of screening, e.g., early recall rate, detection rate, and interval cancers as well of proportion of advanced cancers, were descriptively evaluated and, if informative, group differences were tested for statistical significance. Early recall rates were significantly lower in the subsequent screening rounds than in the first one if the MSCT information from the previous screening rounds was available. Detection and biopsy rates were approxim...Continue Reading

References

Jul 26, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A Hackshaw
Aug 30, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Andrea Lopes PegnaUNKNOWN ITALUNG Study Research Group
Jul 1, 2011·The New England Journal of Medicine·UNKNOWN National Lung Screening Trial Research TeamJoRean D Sicks
Jan 26, 2013·American Journal of Respiratory and Critical Care Medicine·Nanda HorewegHarry J de Koning
May 24, 2013·The New England Journal of Medicine·Timothy R ChurchSarah Baum
Jul 31, 2013·Journal of Surgical Oncology·John K FieldUNKNOWN European Randomized Screening Trial Group
Sep 6, 2013·The New England Journal of Medicine·Denise R AberleUNKNOWN National Lung Screening Trial Research Team

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Citations

Feb 6, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Mario SilvaUgo Pastorino
Jan 28, 2016·Journal of Cancer Research and Clinical Oncology·M BadeN Becker
Mar 2, 2016·American Journal of Respiratory and Critical Care Medicine·Anil Vachani, James R Jett
May 24, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Gaëlle CoureauSimone Mathoulin-Pélissier
Jul 15, 2016·Der Radiologe·O von Stackelberg, H-U Kauczor
Aug 10, 2016·Der Radiologe·N Becker, S Delorme
Aug 22, 2016·Clinical Oncology : a Journal of the Royal College of Radiologists·D R Baldwin, M E J Callister
Oct 23, 2016·Journal of Proteome Research·Ingrid BroodmanTheo Luider
Dec 23, 2016·Expert Review of Respiratory Medicine·Marjolein A HeuvelmansMatthijs Oudkerk
Jun 3, 2017·Acta Oncologica·Jesper Holst PedersenTomas Gudbjartsson
May 26, 2016·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Maurizio InfanteUgo Pastorino
Jan 27, 2018·Wiener klinische Wochenschrift·Richard SchmidtGeorg-Christian Funk
Apr 6, 2017·Thorax·Eugenio PaciUNKNOWN and the ITALUNG Working Group
Oct 12, 2018·International Journal of Radiation Biology·Takeshi Nawa
Nov 2, 2018·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Bernd KowallAndreas Stang
May 3, 2019·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M RotaP Boffetta
Apr 3, 2019·Annals of Oncology : Official Journal of the European Society for Medical Oncology·U PastorinoA Marchianò
Nov 28, 2017·The British Journal of Radiology·Mario SilvaNicola Sverzellati
Jun 5, 2019·International Journal of Cancer. Journal International Du Cancer·Nikolaus BeckerStefan Delorme
Jan 18, 2019·Experimental and Therapeutic Medicine·Bertram J JobstJulia Ley-Zaporozhan
Jun 25, 2020·Japanese Journal of Clinical Oncology·Osamu HemmiManami Inoue
Dec 9, 2017·Frontiers of Medicine·Hongbing Shen
Dec 16, 2018·European Radiology·Bertram J JobstMark O Wielpütz
Jun 26, 2020·Journal of General Internal Medicine·Richard M HoffmanRobert G Badgett
Sep 19, 2020·European Clinical Respiratory Journal·Ane Aamli GagnatRune Nielsen
Nov 7, 2018·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Michael SchlanderTao Ran
Jan 30, 2020·Revista da Associação Médica Brasileira·Xue TangYehuan Sun
Oct 3, 2015·Deutsches Ärzteblatt International·Hans-Werner Hense
Mar 3, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Aaron R Dezube, Michael T Jaklitsch
Mar 10, 2021·JAMA : the Journal of the American Medical Association·Daniel E JonasRussell P Harris
Jan 29, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·U PastorinoA Marchianò
Mar 16, 2021·Journal of the Royal Society of Medicine·Stephen H BradleyMartyn Pt Kennedy
Feb 20, 2019·Bulletin du cancer·Gaëlle Coureau, Fleur Delva
Apr 19, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Anton SchreuderMathias Prokop

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