Randomized trial and pharmacokinetic study of pegfilgrastim versus filgrastim after dose-intensive chemotherapy in young adults and children with sarcomas.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Elizabeth FoxFrank M Balis

Abstract

To compare the effectiveness, tolerance, and pharmacokinetics of a single dose of pegfilgrastim to daily filgrastim in children and young adults with sarcomas treated with dose-intensive combination chemotherapy. Patients were randomized to receive a single dose of 100 mcg/kg of pegfilgrastim s.c. or 5 mcg/kg/day of filgrastim s.c., daily until neutrophil recovery after two treatment cycles with vincristine, doxorubicin, and cyclophosphamide (VDC) and two cycles of etoposide and ifosfamide (IE). The duration of severe neutropenia (absolute neutrophil count, < or =500/mcL) during cycles 1 to 4 and cycle duration for all cycles were compared. Pharmacokinetics of pegfilgrastim and filgrastim and CD34+ stem cell mobilization were studied on cycle 1. Growth factor-related toxicity, transfusions, and episodes of fever and neutropenia and infections were collected for cycles 1 to 4. Thirty-four patients (median age, 20 years; range 3.8-25.8) were enrolled, and 32 completed cycles 1 to 4. The median (range) duration of absolute neutrophil count of <500/mcL was 5.5 (3-8) days for pegfilgrastim and 6 (0-9) days for filgrastim (P = 0.76) after VDC, and 1.5 (0-4) days for pegfilgrastim and 3.75 (0-6.5) days for filgrastim (P = 0.11) after ...Continue Reading

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Citations

Jul 31, 2013·Annals of Hematology·S ZeynalovaUNKNOWN German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL)
Oct 19, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Sibylle LoiblUNKNOWN GBG/AGO/NOGGO study groups
Oct 22, 2015·Expert Opinion on Biological Therapy·Matteo LambertiniPaolo Pronzato
Apr 26, 2015·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Jew-Win KuanKian-Meng Chang
Jun 28, 2015·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Musa Karakukcu, Ekrem Unal
May 13, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Hien K DuongPaul A Carpenter
Jun 3, 2015·Radiation Research·Kim G HankeyThomas J MacVittie
Dec 18, 2016·Cancer Chemotherapy and Pharmacology·Margarita B BelogurovaAndreas Lammerich
Jul 15, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas J SmithJames O Armitage
Jun 23, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ruth LadensteinAndrew Pearson
Jan 13, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Julien HadouxPatricia Pautier
Sep 9, 2019·Advanced Drug Delivery Reviews·Venkata K YellepeddiElizabeth Nance
Aug 18, 2021·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·Laura Schlenker, Renee C B Manworren

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