Randomized trial comparing epirubicin, cisplatin, and fluorouracil versus fluorouracil, doxorubicin, and methotrexate in advanced esophagogastric cancer

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
A WebbM Meehan

Abstract

We report the results of a prospectively randomized study that compared the combination of epirubicin, cisplatin, and protracted venous infusion fluorouracil (5-FU) (ECF regimen) with the standard combination of 5-FU, doxorubicin, and methotrexate (FAMTX) in previously untreated patients with advanced esophagogastric cancer. Two hundred seventy-four patients with adenocarcinoma or undifferentiated carcinoma were randomized and analyzed for survival, tumor response, toxicity, and quality of life (QL). The overall response rate was 45% (95% confidence interval [CI], 36% to 54%) with ECF and 21% (95% CI, 13% to 29%) with FAMTX (P = .0002). Toxicity was tolerable and there were only three toxic deaths. The FAMTX regimen caused more hematologic toxicity and serious infections, but ECF caused more emesis and alopecia. The median survival duration was 8.9 months with ECF and 5.7 months with FAMTX (P = .0009); at 1 year, 36% (95% CI, 27% to 45%) of ECF and 21% (95% CI, 14% to 29%) of FAMTX patients were alive. The median failure-free survival duration was 7.4 months with ECF and 3.4 months with FAMTX (P = .00006). The global QL scores were better for ECF at 24 weeks, but the remaining QL data showed no differences between either arm of...Continue Reading

Citations

Oct 6, 2004·Expert Opinion on Pharmacotherapy·Eva GaliziaStefano Cascinu
Dec 6, 2005·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Christine RebischungMireille Mousseau
Oct 10, 2006·Future Oncology·Peter C Thuss-PatiencePeter Reichardt
Oct 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tomislav DragovichJames L Abbruzzese
Aug 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jaffer A AjaniUNKNOWN V-325 Study Group
Aug 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David H Ilson
Apr 22, 2008·São Paulo Medical Journal = Revista Paulista De Medicina·Vanessa de Carvalho FabrícioAuro Del Giglio
Jun 13, 2009·World Journal of Gastroenterology : WJG·Gerardo RosatiLuigi Manzione
Nov 23, 2011·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Katsuhiko HiguchiWasaburo Koizumi
Apr 12, 2017·Journal of Gastrointestinal Cancer·Jorge Hernando-CuberoJaume Capdevila
Apr 5, 2017·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·A G M T PowellW G Lewis
Aug 30, 2017·The Cochrane Database of Systematic Reviews·Anna Dorothea WagnerSusanne Unverzagt
Nov 15, 2018·Current Oncology Reports·Dara Bracken-ClarkeAnne M Horgan
Dec 7, 2018·Japanese Journal of Clinical Oncology·Hiroyuki AraiTakako Eguchi Nakajima
Dec 12, 2018·Expert Opinion on Pharmacotherapy·Samuel Lee, Deirdre J Cohen
Jun 5, 2002·Anti-cancer Drugs·Daniel G Haller, Jean-Louis Misset
Mar 22, 2001·The British Journal of Surgery·J I GehR Glynne-Jones
Sep 1, 2001·Journal of Advanced Nursing·L Hakamies-BlomqvistC Blomqvist
May 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N C TebbuttD Cunningham
Jun 30, 2000·Journal of Clinical Gastroenterology·R De VivoB Daniele
Feb 16, 2006·The Oncologist·Michael HejnaMarkus Raderer
Jul 15, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M H Kulke
Apr 18, 2003·The European Journal of Surgery = Acta Chirurgica·Karl-Gunnar JanungerBengt Glimelius
Nov 30, 2006·British Journal of Cancer·E MochikiUNKNOWN North Kanto Gastric Cancer Study Group

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.