PMID: 11921128Mar 29, 2002Paper

Randomized trial comparing primidone initiation schedules for treating essential tremor

Movement Disorders : Official Journal of the Movement Disorder Society
Padraig O'Suilleabhain, R B Dewey

Abstract

Early side effects are common when primidone is used to treat essential tremor, with as many as one-third of patients failing to tolerate the tablets. Lower doses can be prescribed initially using a suspension formulation. We suspected suspension initiation would result in fewer early side effects, allow better acclimatization, and improve compliance. Forty patients with essential tremor were randomized to begin primidone treatment using either 2.5 mg doses in the suspension form or 25 mg doses in the tablet form. Doses gradually increased over 3 weeks to 150 mg/day. This was a double-blind, double-dummy trial. Medication cessation due to side effects was designated the primary end-point. Four patients in the suspension group and two in the tablet group dropped out due to early side effects, resulting in a relative risk of 1.9 (95% confidence interval 0.4 to 9.2). Side effects in the first 48 hours of treatment were equally common, affecting seven subjects in each group. Treatment benefits were the same in both groups. We concluded that use of a very low initial dose and a graduated titration schedule in suspension formulation did not appear to improve primidone tolerability. If anything, compliance tended to be worse when comp...Continue Reading

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Apr 11, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·P E O'Suilleabhain, R B Dewey

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Citations

Jul 25, 2013·Current Treatment Options in Neurology·Theresa A ZesiewiczKelly L Sullivan
Nov 23, 2006·Nature Clinical Practice. Neurology·Julián Benito-León, Elan D Louis
Nov 18, 2010·Drugs·Reza Sadeghi, William G Ondo
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Sep 27, 2006·Clinics in Geriatric Medicine·Elan D Louis
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May 3, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Joaquim J FerreiraUNKNOWN MDS Task Force on Tremor and the MDS Evidence Based Medicine Committee
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Aug 31, 2020·Tremor and Other Hyperkinetic Movements·Stuart H IsaacsonRajesh Pahwa
Sep 1, 2004·The Neurologist·Kelly L SullivanTheresa A Zesiewicz

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