Randomized Trial Evaluating Percutaneous Coronary Intervention for the Treatment of Chronic Total Occlusion

Circulation
Seung-Whan LeeSeung-Jung Park

Abstract

Procedural results for percutaneous coronary intervention (PCI) in coronary vessels with chronic total occlusion (CTO) have improved in recent years, and PCI strategies have moved toward more complete revascularization with more liberal use of CTO-PCI. However, evidence evaluating CTO-PCI is limited to observational studies and small clinical trials. In this open-label, multicenter, randomized, noninferiority trial, PCI-eligible patients were assigned to receive either 1 of 2 strategies: PCI or no PCI for the qualifying de novo CTO lesion with the option for PCI of obstructive non-CTO lesions at the discretion of the operator. The primary end point was a composite of death, myocardial infarction, stroke, or any revascularization. Health-related quality of life was assessed at baseline and at 1, 6, 12, 24, and 36 months. Because of slow recruitment, the trial was stopped before completion of the 1284 planned enrollments. Between March 2010 and September 2016, 834 patients were randomly assigned to the CTO-PCI (n=417) or no CTO-PCI (n=398) strategy. Among the patients assigned to the no CTO-PCI strategy, 78 (19.6%) crossed over to receive staged CTO-PCI within 3 days of randomization. The overall CTO-PCI success rate was 90.6%. S...Continue Reading

References

Sep 15, 1990·The American Journal of Cardiology·L FinciW Rutishauser
Feb 1, 1995·Anaesthesia·S P CheemaS Sabanathan
Aug 9, 2001·Annals of Medicine·R Rabin, F de Charro
Oct 26, 2007·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Héctor M García-GarcíaPatrick W Serruys
Feb 22, 2008·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Alexander HirschFelix Zijlstra
Nov 14, 2008·Bulletin of Environmental Contamination and Toxicology·W D Di MarzioD M P Galassi
Feb 7, 2009·Journal of the American College of Cardiology·W Douglas WeaverJoseph D Babb
Feb 21, 2009·The New England Journal of Medicine·Patrick W SerruysUNKNOWN SYNTAX Investigators
Jun 23, 2009·JACC. Cardiovascular Interventions·J Aaron GranthamBarry D Rutherford
Jun 27, 2009·Journal of the American College of Cardiology·Michael A KutcherUNKNOWN National Cardiovascular Data Registry
Aug 12, 2009·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Emmanouil S BrilakisWilliam L Lombardi
Sep 16, 2009·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Zhu Jun ShenUNKNOWN Interventional Cardiologists at Thoraxcentre in 2000-2003
Sep 29, 2009·Journal of cardiology·Pablo AvanzasJuan Carlos Kaski
Oct 17, 2009·Journal of the American College of Cardiology·David E KandzariUNKNOWN American College of Cardiology Interventional Scientific Council
Nov 26, 2009·European Heart Journal·Petr WidimskyUNKNOWN European Association for Percutaneous Cardiovascular Interventions
Jan 23, 2010·The International Journal of Cardiovascular Imaging·UNKNOWN ASCI CCT & CMR Guideline Working GroupUNKNOWN Asian Society of Cardiovascular Imaging Cardiac Computer Tomography and Cardiac Magnetic Resonance Imaging Guideline Working
Feb 23, 2010·JACC. Cardiovascular Interventions·Craig A Thompson
Jun 9, 2010·Equine Veterinary Journal·M L PetersonC W McIlwraith
Jul 20, 2010·Journal of Interventional Cardiology·Cedric DelhayeRon Waksman
Aug 21, 2010·JACC. Cardiovascular Interventions·Bimmer E P M ClaessenGeorge D Dangas
Apr 5, 2011·The Journal of Allergy and Clinical Immunology·David B K GoldenUNKNOWN Joint Council of Allergy, Asthma and Immunology
Aug 2, 2011·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·E Marc JolicœurJames E Tcheng
Mar 10, 2012·Journal of the American College of Cardiology·Paul FeferBradley H Strauss
Apr 21, 2012·JACC. Cardiovascular Interventions·Emmanouil S BrilakisCraig A Thompson
May 15, 2012·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Georgios SianosUNKNOWN EuroCTO Club
Oct 22, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Omar M JeroudiEmmanouil S Brilakis
Jul 19, 2014·Journal of the American College of Cardiology·Sudhakar GeorgeUNKNOWN National Institute for Cardiovascular Outcomes Research

❮ Previous
Next ❯

Citations

Jul 30, 2019·Circulation·Emmanouil S BrilakisStephane Rinfret
Jan 7, 2020·European Heart Journal·Andreas BaumbachWilliam Wijns
Feb 14, 2020·Current Cardiology Reports·Nils P Johnson, K Lance Gould
Feb 25, 2020·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Chao GaoPatrick W Serruys
Jul 1, 2020·Expert Review of Cardiovascular Therapy·Ilias NikolakopoulosEmmanouil S Brilakis
Dec 4, 2019·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Yong-Hoon YoonSeung-Jung Park
Jan 29, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Alexandre QuadrosLucio Padilla
Jul 21, 2020·Expert Review of Cardiovascular Therapy·Amira AssafSing-Chien Yap
Aug 23, 2020·Biomedicines·Kudrat Rakhimov, Tommaso Gori
Dec 5, 2019·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·H W van der WerfE Lipšic
Feb 19, 2020·Circulation. Cardiovascular Interventions·John A Bittl
Sep 4, 2020·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Hyungdon KookCheol Woong Yu
Mar 5, 2020·Journal of Community Hospital Internal Medicine Perspectives·Noman LateefMark Holmberg
Oct 9, 2019·Expert Review of Medical Devices·Giulia IannacconeRoberto Diletti
Mar 4, 2020·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Stefan P SchumacherPaul Knaapen
Aug 9, 2020·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Carlo Di Mario, Gabriele Bambagioni
Oct 8, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Usaid K AllahwalaRavinay Bhindi
Dec 2, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·C WiefelsA Y Chong
Dec 3, 2020·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·A van VeelenUNKNOWN PCI Registration Committee of the Netherlands Heart Registration
Oct 20, 2020·The Canadian Journal of Cardiology·Luiz F Ybarra, Stéphane Rinfret
May 16, 2020·Current Opinion in Cardiology·Keyvan Karimi GalougahiZiad A Ali
Aug 5, 2020·European Journal of Clinical Investigation·Tao TianWeixian Yang
Feb 5, 2021·Journal of the American College of Cardiology·Hideyuki KawashimaUNKNOWN SYNTAX Extended Survival Investigators
Feb 6, 2021·JACC. Cardiovascular Interventions·Luiz F Ybarra, Rodrigo Bagur
Oct 17, 2020·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·A van VeelenJ P S Henriques
Jan 11, 2021·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Gerald S Werner
Feb 6, 2021·JACC. Cardiovascular Interventions·Changdong GuanBo Xu
Mar 3, 2021·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Lei SongBo Xu
Mar 4, 2021·European Heart Journal Supplements : Journal of the European Society of Cardiology·Mila Menozzi, Giancarlo Piovaccari

❮ Previous
Next ❯

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